Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.

A A Chulanova, A M Smakhtina, G S Mal, I I Bobyntsev, M Yu Smakhtin, E S Mishina, P M Kopeykin, E G Bogomolova

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A A ChulanovaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.

A M SmakhtinaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. smaxtina2012@yandex.ru.

G S MalKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.

I I BobyntsevKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.

M Yu SmakhtinKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.

E S MishinaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.

P M KopeykinIQ Chemical LLC, St. Petersburg, Russia.

E G BogomolovaIQ Chemical LLC, St. Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the reparative and antioxidant effects of thymogen (10 and 100 μg/kg) and its modifications in equimolar doses (12 and 120 μg/kg) obtained by attaching the amino acid D-alanine (D-Ala) to the N- or C-terminus of the peptide molecule. A single intraperitoneal injection of hydrazine hydrochloride caused a decrease in catalase activity and an increase in molondialdehyde (MDA) concentration. Administration of peptides in lower doses inhibited LPO and stimulated reparative regeneration of hepatocytes. Thymogen analogue with D-Ala at the C-terminus was most effective. Increasing the doses of thymogen (100 μg/kg) and its analogues (120 μg/kg) did not lead to further increase in their hepatoprotective activity.

Indexed as

AntioxidantsChemical and Drug Induced Liver InjuryHydrazinesLiverProtective AgentsAnimalsCatalaseHepatocytesLipid PeroxidationMaleMalondialdehydeOligopeptidesRatsRats, WistarAntioxidantsCatalasehydrazineHydrazinesMalondialdehydeOligopeptidesProtective AgentsTP 7D-alaninehepatocyte regenerationhepatoprotectionhydrazine hepatopathythymogen

Identifiers

PMID40442470

DOI10.1063/1.5082194

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.