ArticleCommunications biology2025
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Whole-Transcriptome Landscape Deciphers a ceRNA-Mediated "De-Repression-Activation" Circuit Governing Continuous Estrus in Ovine.Animals : an open access journal from MDPI · 2026Article
- Molecular mechanisms and multi-organ regulatory roles of anti-Müllerian hormone in female reproduction.Communications biology · 2026Review
- GraphBAN-based identification of active ingredients and key gene targets in compound Chinese herbal medicines for polycystic ovary syndrome.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Age at menarche and age-adjusted anti-Müllerian hormone level among women of childbearing age in China.Journal of ovarian research · 2026Article
- Intraovarian injection of autologous platelet-rich plasma combined with peripheral blood mononuclear cells improves ovarian function in advanced-age women with diminished ovarian reserve: a clinical retrospective cohort and single-cell transcriptomic analysis.Journal of ovarian research · 2026Article
- Review
- Comparative analysis of serum anti-Müllerian hormone (AMH) levels in sheep: the role of genetic background and physiological status.Archives animal breeding · 2026Article
- Integrative Network View of PCOS: Organ Crosstalk Driven by the Hyperandrogenemia-Insulin Resistance-Inflammation Triad.Journal of multidisciplinary healthcare · 2026Review
- Multi-omics atlas of ovarian cellular and molecular responses to diabetes.Molecular metabolism · 2026Article
- Integrated transcriptomic and co-expression network analysis identifies immune-metabolic biomarkers of polycystic ovary syndrome in granulosa cells.Journal of ovarian research · 2025Article
- Integrated Whole-Transcriptome Analysis to Elucidate the Core Regulatory Network of circRNA Involved in Ovarian Development and Reproductive Capacity Differences in Sheep: circRNA2058-miR-9226-5p-Animals : an open access journal from MDPI · 2025Article
- Molecular Shadows of Per- and Polyfluoroalkyl Substances (PFASs): Unveiling the Impact of Perfluoroalkyl Substances on Ovarian Function, Polycystic Ovarian Syndrome (PCOS), and In Vitro Fertilization (IVF) Outcomes.International journal of molecular sciences · 2025Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anti-Müllerian Hormone (AMH), secreted by granulosa cells (GCs) of preantral follicles, regulates early-stage follicle growth by inhibiting the activation of primordial follicles. While GCs facilitate follicle development and ovulation through estrogen and progesterone secretion, the role of AMH in sheep GCs and its impact on follicle development remains unclear. Here, we show that exogenous AMH inhibits primordial follicle development utilizing in vitro culture of fetal sheep ovarian cortex model. Knockdown of AMH in sheep GCs increases cell proliferation, decreases apoptosis, and elevates estradiol (E2) secretion, while overexpression has the opposite effects. RNA-seq analysis suggests that AMH modulates genes involved in cell cycle regulation and MAPK signaling. Notably, AMH downregulates estrogen receptor β (ESR2) expression and suppresses FSH-induced upregulation of aromatase (CYP19A1). These findings demonstrate AMH regulates GCs function through multiple pathways, offering insights into sheep fertility and potential targets to enhance reproductive efficiency.
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