Evidence map›Paper›PMID 40442458›Full record

ArticleBiological trace element research2026

Zinc Sulfate Alleviates Olanzapine Induced Alteration in Hepatic Protein Patterns and Antioxidant Defense System in Rats.

Wael Mahmoud Aboulthana, Sherif Abdelmottaleb Moussa, Samir Wassef Aziz, Amal Gouda Hussien, Enayat A Omara, Samir A E Bashandy

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Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wael Mahmoud AboulthanaBiochemistry Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St, P.O. 12622, Dokki, Cairo, Egypt. wmkamel83@hotmail.com.
Sherif Abdelmottaleb MoussaBiochemistry Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St, P.O. 12622, Dokki, Cairo, Egypt.
Samir Wassef AzizBiochemistry Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St, P.O. 12622, Dokki, Cairo, Egypt.
Amal Gouda HussienBiochemistry Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St, P.O. 12622, Dokki, Cairo, Egypt.
Enayat A OmaraPathology Department, National Research Centre, 33 El Bohouth St, P.O. 12622, Dokki, Cairo, Egypt.
Samir A E BashandyPharmacology Department, National Research Centre, 33 El Bohouth St, P.O. 12622, Dokki, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the atypical antipsychotic drugs is olanzapine (OLZ). Enhancing metabolic and detoxifying activities requires zinc (Zn). Thus, the objective of the current study was to determine if Zn supplementation might effectively reduce hepatic lesions induced by OLZ. The oxidative stress, inflammatory, and fibrotic indicators of the liver tissues were evaluated, and electrophoretic methods were used to analyze the native protein and isoenzyme patterns. Furthermore, the liver tissues were examined histopathologically. The dynamic motion of the extracted hemoglobin was also examined. In addition to the serious damage identified histopathologically, our results show that OLZ treatment altered the liver tissue's antioxidant and inflammatory indicators. The zinc sulfate (ZnSO

Indexed as

AntioxidantsAntipsychotic AgentsLiverZinc SulfateAnimalsMaleOlanzapineOxidative StressRatsRats, WistarAntioxidantsAntipsychotic AgentsOlanzapineZinc SulfateAntioxidantsDynamic motion of hemoglobinElectrophoresisIsoenzymesOlanzapine

Identifiers

PMID40442458
PMCPMC12847163

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.