Evidence map›Paper›PMID 40442425›Full record

ArticleScientific reports2025

Socioeconomic factors, brain-derived neurotrophic factor Val66Met polymorphism, and cortical structure in children and adolescents.

Emily C Merz, Filip Morys, Melissa Hansen, Jordan Strack, Lydia Jacobs, Uku Vainik, Mari Shishikura, Brent Myers

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Emily C MerzDepartment of Psychology, Colorado State University, Fort Collins, CO, USA. emily.merz@colostate.edu.
Filip MorysMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Melissa HansenDepartment of Psychology, Colorado State University, Fort Collins, CO, USA.
Jordan StrackDepartment of Psychology, Colorado State University, Fort Collins, CO, USA.
Lydia JacobsDepartment of Psychology, Colorado State University, Fort Collins, CO, USA.
Uku VainikMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Mari ShishikuraMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Brent MyersDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Variability in associations between socioeconomic status and cortical gray matter may be due in part to the common, functional brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, which alters BDNF signaling. In this study, we examined whether BDNF Val66Met genotype moderated the associations between socioeconomic factors (family income, parental education) and cortical surface area (SA) and thickness (CT) in two large independent samples of typically-developing children and adolescents. Participants were 3- to 21-year-olds (N = 383; 47% female) from the Pediatric Imaging, Neurocognition, and Genetics (PING) study and 11- to 14-year-olds (N = 2566; 46% female) in the Adolescent Brain Cognitive Development (ABCD) study. High-resolution, T1-weighted magnetic resonance imaging data were acquired in both studies. Analyses were conducted on global and regional SA and CT. In the PING sample, BDNF Val66Met genotype significantly moderated the association between family income and total SA and SA in the left fusiform gyrus. In the ABCD sample, there were no significant interactions for global or regional SA or CT. Collectively, these results suggest that BDNF Val66Met genotype may not explain variability in associations between socioeconomic factors and SA or CT in children and adolescents.

Indexed as

Brain-Derived Neurotrophic FactorCerebral CortexPolymorphism, Single NucleotideAdolescentChildChild, PreschoolCognitionFemaleGenotypeGray MatterHumansMagnetic Resonance ImagingMaleSocioeconomic FactorsYoung AdultBDNF protein, humanBrain-Derived Neurotrophic FactorCortical surface areaCortical thicknessFamily incomeGene-by-environment interactionNeurotrophinsParental education

Identifiers

PMID40442425
PMCPMC12122700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.