ReviewAdvances in experimental medicine and biology2025
Rett Syndrome: Thinking Beyond Brain Borders.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- MECP2 mutations rewire human ESC fate and bias cortical lineage commitment.Stem cell reports · 2026Article
- MeCP2 at the crossroads of hypoxia, oxidative stress, and gene regulation in Rett syndrome.Epigenomics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rett Syndrome (RTT) is a severe neurological disorder caused by mutations in the MECP2 gene. This disorder primarily affects brain development, leading to profound cognitive and motor impairments. Conventionally, research on RTT has concentrated on the neurological impact of MECP2 mutations. However, other evidence suggests that the influence of RTT extends beyond neural boundaries, impacting a broad spectrum of other tissues and organ systems. This chapter provides an overview of identified abnormalities in respiratory, skeletal, cardiac, liver, endocrine, urinary, immune, and gastrointestinal systems in patients with RTT or related disease models. We further explore the potential pathways involved in the brain-body circuit and their impact on the development of RTT. These insights not only enhance our understanding of the multi-system involvement in RTT, but also reveal the necessity for a more comprehensive approach to investigating the systemic courses of neurological disorders.
Indexed as
Identifiers
40442389What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.