Evidence map›Paper›PMID 40442362›Full record

ArticleEuropean radiology2025

Early intervention in knee osteoarthritis with genicular artery embolization is associated with improved clinical outcomes.

Tyler Callese, Lucas R Cusumano, Hiro Sparks, Kara Masterson, Scott Genshaft, Jessica K Stewart, Siddharth A Padia

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In one paragraph

Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tyler CalleseDivision of Interventional Radiology, University of California Los Angeles, Los Angeles, CA, USA.
Lucas R CusumanoDivision of Interventional Radiology, University of California Los Angeles, Los Angeles, CA, USA.
Hiro SparksDivision of Interventional Radiology, University of California Los Angeles, Los Angeles, CA, USA.
Kara MastersonDivision of Interventional Radiology, University of California Los Angeles, Los Angeles, CA, USA.
Scott GenshaftDivision of Interventional Radiology, University of California Los Angeles, Los Angeles, CA, USA.
Jessica K StewartDivision of Interventional Radiology, University of California Los Angeles, Los Angeles, CA, USA.
Siddharth A PadiaDivision of Interventional Radiology, University of California Los Angeles, Los Angeles, CA, USA. spadia@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-3975-7479

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesGenicular artery embolization (GAE) is an emerging, minimally invasive treatment option for knee OA (osteoarthritis). The purpose of this study was to analyze factors associated with clinical success in GAE. MATERIALS AND

methodsThis IRB-approved, retrospective, single-center study analyzed 236 patients who underwent GAE for knee OA between May 2018 and September 2022. Clinical, radiographic, and technical variables were analyzed for association with clinical outcomes in GAE. The primary endpoint was clinical success assessed at one year.

resultsOverall clinical success was reported in 128 patients (54.2%). Clinical success was observed in younger patients (67.5 ± 9.4 vs 71.5 ± 11.1 years, p < 0.01) with higher BMI (29.7 ± 5.3 vs 27.6 ± 6.4 kg/m

conclusionGAE is an effective procedure with durable clinical improvement at one year, particularly in younger patients and those with mild-to-moderate knee osteoarthritis. These findings suggest that early intervention with GAE may be appropriate in patients who are not candidates for, or do not desire, total knee arthroplasty. KEY POINTS: Question GAE is a minimally invasive intervention for knee osteoarthritis, however, there is a paucity of evidence describing factors associated with improved clinical outcomes. Findings Factors associated with clinical success in GAE included younger patients and those with early-stage osteoarthritis. Clinical relevance These findings support GAE as an early intervention for patients with symptomatic knee osteoarthritis.

Indexed as

Embolization, TherapeuticOsteoarthritis, KneeAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeEmbolizationInterventional radiologyOsteoarthritisPain management

Identifiers

PMID40442362
PMCPMC12634750

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.