ArticleNpj viruses2025
Influenza A virus NS1 suppresses nuclear speckles promoted gene expression by inhibition of transcription.
Article in Npj viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Nuclear speckles: a fundamental layer of gene regulation.Trends in cell biology · 2026Review
- Nuclear speckles are regulatory hubs for viral and host mRNA expression during HSV-1 infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Chronic Diseases and Influenza Vaccines.Vaccines · 2025Review
- How influenza A virus NS1 impedes transcription of the host cell's messenger RNAs.Npj viruses · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
IAV-NS1 proteins that interact with Cleavage and polyadenylation specific factor 30 are known to inhibit host gene expression. Here we report that in both transfection and infection experiments, a strong attenuation of reporter gene expression is observed when NS1 proteins are fused to protein domains guiding NS1 exclusively to nuclear speckles (NSP). NS1 proteins that are fused to domains that guide them to nuclear or non-nuclear compartments other than NSP show little or no ability to attenuate reporter gene expression. An NSP-localized NS1-effector domain is sufficient to inhibit gene expression. The protein SON is an essential component of NSP. SiRNA-mediated suppression of SON reduced the ability of NS1 to suppress the expression of a reporter gene relative to cells with fully functional NSP. Lastly, we demonstrate that the NS1-mediated suppression relies on transcriptional inhibition. Our data suggest that IAV-NS1 suppresses NSP-promoted gene expression by inhibition of transcription.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.