ArticlePediatric radiology2025
Free-running isotropic three-dimensional cine magnetic resonance imaging with deep learning image reconstruction.
Article in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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6 authors.
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Abstract
backgroundCardiovascular magnetic resonance (CMR) cine imaging is the gold standard for assessing ventricular volumes and function. It typically requires two-dimensional (2D) bSSFP sequences and multiple breath-holds, which can be challenging for patients with limited breath-holding capacity. Three-dimensional (3D) cardiovascular magnetic resonance angiography (MRA) usually suffers from lengthy acquisition. Free-running 3D cine imaging with deep learning (DL) reconstruction offers a potential solution by acquiring both cine and angiography simultaneously.
objectiveTo evaluate the efficiency and accuracy of a ferumoxytol-enhanced 3D cine imaging MR sequence combined with DL reconstruction and Heart-NAV technology in patients with congenital heart disease. MATERIALS AND
methodsThis Institutional Review Board approved this prospective study that compared (i) functional and volumetric measurements between 3 and 2D cine images; (ii) contrast-to-noise ratio (CNR) between deep-learning (DL) and compressed sensing (CS)-reconstructed 3D cine images; and (iii) cross-sectional area (CSA) measurements between DL-reconstructed 3D cine images and the clinical 3D MRA images acquired using the bSSFP sequence. Paired t-tests were used to compare group measurements, and Bland-Altman analysis assessed agreement in CSA and volumetric data.
resultsSixteen patients (seven males; median age 6 years) were recruited. 3D cine imaging showed slightly larger right ventricular (RV) volumes and lower RV ejection fraction (EF) compared to 2D cine, with a significant difference only in RV end-systolic volume (P = 0.02). Left ventricular (LV) volumes and EF were slightly higher, and LV mass was lower, without significant differences (P ≥ 0.05). DL-reconstructed 3D cine images showed significantly higher CNR in all pulmonary veins than CS-reconstructed 3D cine images (all P < 0.05).
conclusionHighly accelerated free-running 3D cine imaging with DL reconstruction shortens acquisition times and provides comparable volumetric measurements to 2D cine, and comparable CSA to clinical 3D MRA.
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