ArticleScientific reports2025
Exploring the metabolic and cuticular mechanisms of increased pyrethroid resistance in Anopheles gambiae S.l populations from Ghana.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Operationalising Environmental DNA (eDNA) Detection of Major Malaria Vector Species in Ghana.Molecular ecology resources · 2026Article
- Larval habitat drives differential selection pressures on genetic insecticide resistance and metabolic enzyme plasticity in Anopheles gambiae s.l during laboratory colonization.Scientific reports · 2026Article
- Pyrethroid-resistance in Anopheles gambiae s.l (Culicidae) populations from the Sudan Savannah ecoregion in Nigeria is partly mediated by knockdown mutation.BMC research notes · 2026Article
- Genomic insights into the spread and evolution of insecticide resistance variants in Anopheles gambiae s.l. from Burkina Faso.Scientific reports · 2026Article
- Spatial and temporal signatures of genomic insecticide resistance in the Anopheles arabiensis mosquito malaria vector from Ethiopia.Research square · 2026Article
- Comparative analysis reveals concentration-dependent and site-specific detoxification gene expression patterns in pyrethroid-resistant Anopheles gambiae s.l. from Accra, Ghana.Scientific reports · 2026Article
- Spatial Heterogeneity ofJournal of parasitology research · 2026Review
- Genomic insights into the spread and evolution of insecticide resistance in Anopheles gambiae s.l. from Burkina Faso.Research square · 2025Article
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6 authors.
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Abstract
Increasing insecticide resistance in malaria vectors threatens the efficacy of current control tools, however knowledge of metabolic and cuticular mechanisms is widely lacking in Ghana. We examined the metabolic and cuticular resistance mechanisms in Anopheles gambiae mosquitoes from coastal and sahel zones of Ghana. WHO susceptibility tests and synergist assays were performed on F0 field collected An. gambiae s.l. Gene expression profiles of eight key metabolic and cuticular genes were determined using qRT-PCR. Moderate to high pyrethroid resistance (< 70%) were observed across all the sites. Piperonyl butoxide significantly increased susceptibility to pyrethroids across all sites and insecticides, implicating P450s. Gene expression analysis revealed overexpression of metabolic and cuticular resistance genes in field An. gambiae populations compared to the susceptible Kisumu strain. CYP6M2 and CYP6P3 were the most overexpressed metabolic genes in pyrethroid-resistant mosquitoes, compared to the pyrethroid susceptible mosquitoes in the coastal (FC: 122.28 and 231.86, p < 0.05) and sahel (FC: 344.955 and 716.37, p < 0.001) zones respectively. CYP4G16 (previously associated with cuticular resistance) was significantly overexpressed in only resistant mosquitoes (FC: 3.32-30.12, p < 0.05). Overexpression of metabolic and cuticular resistance genes in local malaria vectors highlights the need to intensify insecticide resistance management strategies to control malaria in Ghana.
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