ArticleScientific reports2025
Associations between physical activity and brain structure in a large community cohort.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- From Fitness to Cognition: Machine-Learning Prediction of Cognitive Performance Using Physiological Parameters in Healthy Adults.Medicine and science in sports and exercise · 2026Article
- Physical Activity Is Associated With Age-Related Differences in Hippocampal Macrostructure and Microstructure in Middle-Aged and Older Adults.Hippocampus · 2026Article
- Physical function impacts hearing without mediation from systolic blood pressure.Scientific reports · 2026Article
- Relationship between cardiac index and brain volume in the UK Biobank.Cerebral circulation - cognition and behavior · 2026Article
- Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- fMRI insights into differential brain activation, executive function, and physical activity in older adults.PloS one · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Low physical activity (PA) and obesity are dementia risk factors, but it is unclear whether the association between PA and brain health is dependent upon degree of obesity. We aimed to examine the association between PA and brain structure and explore whether it varies by body mass index (BMI). We examined the associations between accelerometer-measured PA and magnetic resonance imaging-measured brain structure using cross-sectional data from a population-based cohort of people in midlife (UK Biobank). Using regression modelling, we explored whether these associations were mediated by BMI or other cardiometabolic risk factors. Complete data were available for 16,725 participants (median age 65 years, 55% women, median BMI 26). Greater PA was positively associated with total brain (β = 3.67, p < 0.0001), grey matter (β = 3.12, p < 0.0001), white matter (β = 0.43, p < 0.0001) and total hippocampal volumes (β = 0.05, p < 0.0001), and inversely associated with white matter hyperintensity volume (β = - 4.6 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.