Evidence map›Paper›PMID 40442153›Full record

ArticleScientific reports2025

Characterization of atomization and delivery efficiency of exogenous surfactant in preterm infant lungs using an ex vivo respiratory model.

Ghalia Kaouane, Jean-François Berret, Yannick Cremillieux, Noël Pinaud, Fanny Munsch, Bei Zhang, Michael Fayon, Rémy Gérard, Eric Dumas De La Roque, Sophie Perinel-Ragey and 2 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ghalia KaouaneMines Saint-Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, Saint-Etienne, 42023, France.
Jean-François BerretLaboratory of Matter and Complex Systems, CNRS, UMR 7057, Université Paris Cité, Paris, France.
Yannick CremillieuxInstitute of Molecular Sciences, CNRS, UMR 5255, University of Bordeaux, Bordeaux, France.
Noël PinaudInstitute of Molecular Sciences, CNRS, UMR 5255, University of Bordeaux, Bordeaux, France.
Fanny MunschInstitute of Bioimaging, University of Bordeaux, Bordeaux, France.
Bei ZhangCanon Medical Systems Europe, Zoetermeer, The Netherlands.
Michael FayonDepartment of Pediatrics, Bordeaux University Hospital (CHU Bordeaux), CIC-P INSERM 1401 & University of Bordeaux, Bordeaux, France.
Rémy GérardDepartment of Pediatrics, Bordeaux University Hospital (CHU Bordeaux), CIC-P INSERM 1401 & University of Bordeaux, Bordeaux, France.
Eric Dumas De La RoqueCardiothoracic Research Center of Bordeaux, INSERM U1045, Bordeaux, 33000, France.
Sophie Perinel-RageyJean Monnet University, Saint-Étienne, INSERM SAINBIOSE U1059, Saint-Étienne, 42023, France.
Lara LeclercMines Saint-Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, Saint-Etienne, 42023, France.
Jérémie PourchezMines Saint-Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, Saint-Etienne, 42023, France. pourchez@emse.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Administration of pulmonary surfactant is crucial for the treatment of respiratory distress syndrome (RDS) in preterm infants. The aim of this study is to evaluate the potential of Curosurf atomization via the Endosurf device, a recently developed spray technology, as a promising approach for surfactant delivery in infants with RDS. A comprehensive analysis was performed to evaluate the physicochemical properties of atomized Curosurf, including its surface tension and rheology. The size distribution of Curosurf vesicles was also investigated. An ex vivo respiratory model based on rabbit lungs breathing through an instrumented hypobaric chamber representing the thorax of a preterm infant was developed to provide proof of concept for regional aerosol deposition of atomized Curosurf. The atomization of Curosurf with the innovative Endosurf device did not significantly alter surface tension, but reduced vesicle size and promoted homogeneous distribution of Curosurf in the lungs. Rheological measurements showed the viscoelastic complexity of atomized Curosurf. This preliminary study confirmed the promising potential of Curosurf atomization via the Endosurf device for the distribution of surfactant in the lungs of infants with RDS. These advances could help to improve the treatment of RDS in preterm infants and offer new perspectives for healthcare professionals and affected families.

Indexed as

Biological ProductsLungPulmonary SurfactantsRespiratory Distress Syndrome, NewbornAdministration, InhalationAnimalsHumansInfant, NewbornInfant, PrematureNebulizers and VaporizersRabbitsRheologySurface TensionBiological ProductsPulmonary SurfactantsCurosurfEndosurf medical deviceExogenous surfactantEx vivo respiratory modelRespiratory distress syndrome (ARDS)Surfactant atomization

Identifiers

PMID40442153
PMCPMC12122843

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.