Evidence map›Paper›PMID 40441947›Full record

ArticleAcademic radiology2025

Assessment of Regional 3D Hemi-diaphragmatic Motion Via Free-breathing Dynamic MRI in Pediatric Thoracic Insufficiency Syndrome.

Mahdie Hosseini, Jayaram K Udupa, You Hao, Yubing Tong, Caiyun Wu, Yusuf Akhtar, Shiva Shaghaghi, Mostafa Alnoury, Sina Dindarian, Joseph M McDonough and 6 more

Abstract read
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In one paragraph

Article in Academic radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Mahdie HosseiniMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.).
Jayaram K UdupaMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.). Electronic address: jay@pennmedicine.upenn.edu.
You HaoMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.).
Yubing TongMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.).
Caiyun WuMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.).
Yusuf AkhtarMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.).
Shiva ShaghaghiMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.).
Mostafa AlnouryMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.).
Sina DindarianMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.).
Joseph M McDonoughChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania (J.M.M., D.M.B., S.G., O.H.M., P.J.C., J.B.A.).
David M BikoChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania (J.M.M., D.M.B., S.G., O.H.M., P.J.C., J.B.A.).
Samantha GogelChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania (J.M.M., D.M.B., S.G., O.H.M., P.J.C., J.B.A.).
Oscar H MayerChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania (J.M.M., D.M.B., S.G., O.H.M., P.J.C., J.B.A.).
Patrick J CahillChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania (J.M.M., D.M.B., S.G., O.H.M., P.J.C., J.B.A.).
Drew A TorigianMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.H., J.K.U., Y.H., Y.T., C.W., Y.A., S.S., M.A., S.D., D.A.T.).
Jason B AnariChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania (J.M.M., D.M.B., S.G., O.H.M., P.J.C., J.B.A.).

Funding

Virtual growing child 5-dimensional functional models for treating respiratory anomaliesR01HL150147 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI TORIGIAN, DREW, UDUPA, JAYARAM K · 2020 to 2023
$3.1M
NHLBI NIH HHS R01 HL150147
6 · The paper itself

Abstract

RATIONALE AND

objectivesThoracic insufficiency syndrome (TIS) affects ventilatory function due to spinal and thoracic deformities limiting lung space and diaphragm motion. Corrective surgery helps normalize skeletal anatomy, restoring diaphragm motion. This study employs free-breathing dynamic MRI (dMRI) and quantifies the 3D motion of each hemi-diaphragm surface in normal and TIS patients, and evaluates the effects of surgical intervention. MATERIALS AND

methodsIn a retrospective study of 149 pediatric patients with TIS and 190 healthy children, we constructed 4D images from free-breathing dMRI and manually delineated the diaphragm at end-expiration (EE) and end-inspiration (EI) time points. We automatically selected 25 points uniformly on both right (RHD) and left hemi-diaphragm (LHD) surface, estimated their relative velocities between EE and EI, and derived mean velocities in 13 homologous regions for each hemi-diaphragm to provide measures of regional 3D hemi-diaphragm motion. Velocity changes after surgery (mean follow-up: 2.4±1.8 years) were assessed compared to before surgery, and compared with velocities in healthy controls.

resultsAfter surgery, the mean diaphragm velocity increased by 311.9% in 71.4% of subjects in the RHD (P=0.013), and by 93.9% in 61.2% of subjects in the LHD (P=0.078). The posterior-central region of the RHD exhibited the highest average velocity post-operatively. Posterior regions showed greater velocity changes after surgery in both RHD and LHD. Surgical correction of thoracic spinal curve displayed stronger correlation with changes in diaphragm velocity than correction in lumbar spinal curve. Following surgery, the anterior regions of the LHD tended to approach a more normal state.

conclusionQuantification of regional motion of the 3D diaphragm surface in normal subjects and TIS patients via free-breathing dMRI is feasible. Derived measurements can be assessed in comparison to normal subjects to study TIS and the effects of surgery.

Indexed as

DiaphragmImaging, Three-DimensionalMagnetic Resonance ImagingRespiratory InsufficiencyAdolescentChildChild, PreschoolFemaleHumansInfantMaleRespirationRetrospective StudiesSyndromeDiaphragmDynamic MRIMotionQuantitative radiologyThoracic insufficiency syndrome (TIS)

Identifiers

PMID40441947
PMCPMC13050460

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.