Evidence map›Paper›PMID 40441865›Full record

ArticleGut2025

Commensal

Pengfei Li, Qiyi Lei, Xinghao Yu, Ying Shen, Yiyin Chen, Chang Hou, Bo Hu, Yanfang Cui, Zhihua Liu, Yi Qin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pengfei LiNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0003-0767-3120
Qiyi LeiNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xinghao YuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ying ShenNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yiyin ChenNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Chang HouNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Bo HuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yanfang CuiNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhihua LiuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0009-0004-8063-3007
Yi QinDepartment of Pharmacy, Clinical Pharmacology Research Lab, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Haiyan LiuImmunology Translational Research Programme, Department of Microbiology of Immunology, Yong Loo Lin School of Medicine, Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore wudepei@suda.edu.cn xuyang1020@126.com lindandan@suda.edu.cn micliuh@nus.edu.sg.
Dandan LinNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China wudepei@suda.edu.cn xuyang1020@126.com lindandan@suda.edu.cn micliuh@nus.edu.sg.
Yang XuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China wudepei@suda.edu.cn xuyang1020@126.com lindandan@suda.edu.cn micliuh@nus.edu.sg.ORCID 0000-0003-4643-2098
Depei WuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China wudepei@suda.edu.cn xuyang1020@126.com lindandan@suda.edu.cn micliuh@nus.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal acute graft-versus-host disease (GI-aGVHD) is one of the main complications of patients undergoing allogenic haematopoietic stem cell transplantation (allo-HSCT). A deeper understanding of the mechanisms of sustaining intestinal homeostasis is essential.

objectiveHere, we investigated micro-organisms and microbial metabolites that were crucial for intestinal homeostasis in the context of GI-aGVHD management.

designWe profiled the gut microbiota, immune indices and gut metabolism of 71 patients undergoing allo-HSCT. Initially, we set up a mouse aGVHD model to confirm the effect of

resultsA higher abundance of

conclusionsT6SS in commensal bacteria could modulate bile acid metabolism, potentially impacting aGVHD outcomes and offering a novel target for therapeutic interventions.

Indexed as

BacteroidesBacteroides fragilisBile Acids and SaltsGastrointestinal MicrobiomeGraft vs Host DiseaseHematopoietic Stem Cell TransplantationType VI Secretion SystemsAdultAnimalsDisease Models, AnimalFemaleHumansMaleMiceMiddle AgedBile Acids and SaltsType VI Secretion SystemsBACTERIAL INTERACTIONSBILE ACID METABOLISMGASTROINTESTINAL TRACTINTESTINAL MICROBIOLOGY

Identifiers

PMID40441865
PMCPMC12573429

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.