Evidence map›Paper›PMID 40441740›Full record

ArticleBMJ open diabetes research & care2025

Differences in fat distribution between metabolically unhealthy people with normal weight versus obesity, NHANES 2011-2018.

Seerat Anand, Tejasvi Pasupneti, Youngju Pak, Sreevastav Teja Kalangi, Rajesh Garg

Abstract readComparative Study
In one paragraph

Article in BMJ open diabetes research & care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Seerat AnandEndocrinology, Diabetes and Metabolism, Harbor-UCLA Medical Center, Torrance, CA, USA.
Tejasvi PasupnetiDepartment of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
Youngju PakEndocrinology, Diabetes and Metabolism, Harbor-UCLA Medical Center, Torrance, CA, USA.
Sreevastav Teja KalangiEndocrinology, Diabetes and Metabolism, Harbor-UCLA Medical Center, Torrance, CA, USA.
Rajesh GargEndocrinology, Diabetes and Metabolism, Harbor-UCLA Medical Center, Torrance, CA, USA rajesh.garg@lundquist.org.ORCID http://orcid.org/0000-0002-7779-1619

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMetabolic abnormalities are present in 15-25% of adults with body mass index (BMI)<25 kg/m RESEARCH DESIGN AND

methodsWe used the National Health and Nutrition Examination Survey data (2011-2018) that included dual energy X-ray absorptiometry. Metabolic dysfunction was defined as the presence of ≥2 components of the metabolic syndrome, excluding obesity. The differences in body fat distribution between unhealthy and healthy individuals were studied with an interaction term to evaluate whether the effect of BMI differs by the metabolic health status.

resultsWe found that both MUL and MUO groups had increased android to gynoid fat ratio as compared with metabolically healthy groups with normal or lean weight (MHL) and metabolically healthy with obesity (MHO), respectively. Total fat and android fat were higher in MUL as compared with MHL individuals, in men as well as in women. Gynoid fat was higher in MUL men but not in women. However, MUO individuals had similar total fat but lower gynoid fat as compared with MHO individuals, in men as well as in women. Android fat was significantly higher in the male MUO group but not in the female MUO group.

conclusionsThe study shows increased android fat as the main abnormality in MUL individuals and decreased gynoid fat as the main abnormality in MUO individuals. The differences in android and gynoid fat patterns between MUL and MUO groups suggest different mechanisms of metabolic dysfunction in people who are lean versus those with obesity.

Indexed as

Body Fat DistributionBody WeightMetabolic SyndromeObesityAbsorptiometry, PhotonAdultBody Mass IndexCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesYoung AdultBody CompositionFat DistributionMetabolic SyndromeObesity

Identifiers

PMID40441740
PMCPMC12121599

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