Trial reportThe Journal of nutrition2025
Milk Protein Glycation Compromises Postprandial Lysine Bioavailability but does not Modulate Postprandial Muscle Protein Synthesis Rates In Vivo in Males: A Double-blind, Randomized Parallel Trial.
Trial report in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Salt Equilibria and Protein Glycation in Young Child Formula.Foods (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndustrial processing and storage of milk products can strongly increase protein glycation level. Previously, we have reported that a high protein glycation level impairs protein digestion, thereby compromising lysine bioavailability. The lower postprandial lysine availability may restrict the anabolic properties of a high glycated protein.
objectivesThe objective of this study was to assess the impact of milk protein glycation on postprandial plasma amino acid availability and subsequent postprandial muscle protein synthesis rates during recovery from a single bout of resistance-type exercise.
methodsForty-five recreationally active, healthy young males participated in this double-blinded, randomized parallel study. After performing a single bout of whole-body resistance-type exercise, subjects ingested 20 g milk protein with either a low (4%; LOW-GLYC) or high (47%; HIGH-GLYC) glycation level or a noncaloric placebo (PLA). Continuous intravenous infusion of L-[ring-
resultsProtein ingestion increased plasma total and essential amino acid concentrations compared with placebo (time × treatment interaction: P < 0.001), with no differences between the low and high glycated milk protein. Plasma lysine availability, assessed over the full 6 h postprandial period, was substantially lower following ingestion of the protein with the high versus low glycation level (-5 ± 7 compared with 10 ± 9 mmol · L
conclusionsIngestion of protein with a higher glycation level attenuates postprandial plasma lysine availability. Milk protein glycation does not modulate postprandial muscle protein synthesis rates during recovery from resistance exercise in healthy, young males. This trial was registered at the Dutch Trial Register as NL8690; https://onderzoekmetmensen.nl/nl/trial/49398.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.