ArticleCell reports methods2025
Quiescent horizontal basal stem cells act as a niche for olfactory neurogenesis in a mouse 3D organoid model.
Article in Cell reports methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Construction ofiScience · 2026Article
- Modelling Olfactory Dysfunction in Rodents Through Intranasal Vanadium Exposure.Animals : an open access journal from MDPI · 2026Review
- Evolving stem cell fate capacities and transcriptional priming in the developing olfactory epithelium.bioRxiv : the preprint server for biology · 2026Article
- Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances.Cell regeneration (London, England) · 2026Review
- Global research trends and hotspot evolution of olfactory dysfunction from 2014 to 2024: a bibliometric analysis.Annals of medicine and surgery (2012) · 2026Review
- Olfactory epithelium organoid models identify Ddit3 as a potential therapeutic target against inflammation-related olfactory sensory neuronal loss and functional deficit.International journal of biological sciences · 2026Article
- Olfactory models as a platform for neuroscience research.Frontiers in cellular neuroscience · 2026Review
- Bioelectronic Interfaces and Sensors for Neural Organoids.Microsystems & nanoengineering · 2025Review
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Authors and funding
8 authors.
Funding
Abstract
The olfactory epithelium contains two basal stem cell populations that facilitate the usually life-long ability for neuronal regeneration that is required for maintaining our sense of smell. Horizontal basal cells (HBCs) are generally quiescent and only become active after direct injury to the epithelium that eliminates more than just the olfactory sensory neurons (OSNs). Globose basal cells (GBCs) lie apical to HBCs and are solely responsible for the generation of olfactory neurons in the undamaged epithelium. Understanding how these two neurogenic stem cell populations are regulated as OSNs are replenished is hampered by a lack of robust culture models. Here, we report the development of a 3D mouse organoid model that recapitulates the neurogenic cascade, forming immature OSNs while maintaining both HBCs and GBCs in culture. We use this model to demonstrate that, despite their relative quiescence, HBCs form a critical niche for the emergence and composition of the organoid.
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Registered trials
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