Evidence map›Paper›PMID 40440589›Full record

ArticleNeurology2025

Haemochromatosis Genotypes and Incident Dementia in a Prospective Study of Older Adults.

Chenglong Yu, Martin Delatycki, Sultana Monira Hussain, John James McNeil, Paul Lacaze, John K Olynyk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [Research progress of inherited liver disease in 2025].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenglong YuSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-0546-2779
Martin DelatyckiDepartment of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
Sultana Monira HussainSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0001-7894-2485
John James McNeilSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-1049-5129
Paul LacazeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-0902-6798
John K OlynykCurtin Medical School, Curtin University, Bentley, Australia; and.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesVariants in the homeostatic iron regulator (

methodThis prospective longitudinal study used data from the Aspirin in Reducing Events in the Elderly trial. Participants had no history of cardiovascular disease, dementia, or cognitive decline at enrollment. Genotyping for

resultsThe study included 12,174 unrelated, healthy participants of European ancestry aged 70 years or older, comprising 5,583 men (45.9%) and 6,591 women (54.1%). The median age was 73.7 years (interquartile range [IQR]: 71.6-76.9) for men and 73.9 years (IQR: 71.7-77.5) for women. Compared with the wild-type group, men with p.Cys282Tyr+/+ ( DISCUSSION: Among initially healthy older adults,

Indexed as

DementiaHemochromatosisHemochromatosis ProteinAgedAged, 80 and overFemaleFerritinsGenotypeHumansIncidenceLongitudinal StudiesMaleProspective StudiesFerritinsHemochromatosis ProteinHFE protein, human

Identifiers

PMID40440589
PMCPMC12123751

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.