Observational studyThe Journal of clinical endocrinology and metabolism2025
Stable Iodine Intake and Thyroid Screening Outcomes After the Fukushima Nuclear Disaster: An Observational Study.
Observational study in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A per- and polyfluoroalkyl substances-based gene signature links prognosis to immune landscapes in thyroid cancer.Translational cancer research · 2026Article
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9 authors.
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Abstract
contextStable iodine intake is crucial in preventing thyroid cancer after radiological emergencies; however, the association between stable iodine intake and thyroid outcomes in children after the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident remains unclear.
objectiveTo describe thyroid screening outcomes and investigate the association between stable iodine intake and those outcomes in children after the FDNPP accident.
methodsThis was an observational study based on data from the regional thyroid screening program conducted by the Research Institute of Radiation Safety for Disaster Recovery Support in Fukushima, Japan. Participants were children born between April 1998 and March 2011 in Miharu Town (n = 1974), where stable iodine intake was implemented during the FDNPP accident. The association between stable iodine intake and thyroid ultrasound results was examined using logistic regression analysis. Coarsened exact matching was used to balance sex and age.
resultsAmong the participants, 1095 (55.5%) consumed stable iodine, whereas 879 (44.5%) did not. In the age- and sex-matched group of 1952 children (1088 in the intake and 864 in non-intake group), no association was observed between stable iodine intake and thyroid screening results indicating the need for a detailed examination (odds ratio: 0.839; 95% CI: 0.393-1.8, P = .647). The volume and parenchymal heterogeneity were not different between these groups.
conclusionStable iodine intake was not associated with thyroid ultrasound screening results, probably because of the low radiation doses following the FDNPP accident. Parenchymal heterogeneity and thyroid volume were similar, supporting the conclusion that the adverse effects of single-dose stable iodine are minimal.
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