Evidence map›Paper›PMID 40440413›Full record

ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026

Interferon-γ Therapy in Patients With Refractory Disseminated Coccidioidomycosis.

Chen Wang, Brenna A LaBere, Michell M Lozano Chinga, Annalie J Harris, Lindsey B Rosen, Amanda Elias Rivera, Eva Le Run, Keith A Sacco, Wassim Ballan, James V Woodward and 19 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Immunomodulation in the Treatment of Disseminated Coccidioidomycosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Type-2 immune skewing in patients with disseminated coccidioidomycosis.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Chen WangImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-4055-7391
Brenna A LaBereDivision of Allergy and Immunology, Phoenix Children's, Phoenix, Arizona, USA.ORCID 0000-0002-7967-7270
Michell M Lozano ChingaDivision of Allergy and Immunology, Phoenix Children's, Phoenix, Arizona, USA.ORCID 0000-0002-9204-702X
Annalie J HarrisImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0009-0007-8231-8002
Lindsey B RosenImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Amanda Elias RiveraImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Eva Le RunImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0009-0003-6744-5848
Keith A SaccoImmunology Department, Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.ORCID 0000-0001-8189-7769
Wassim BallanDivision of Infectious Diseases, Phoenix Children's, Phoenix, Arizona, USA.ORCID 0000-0003-2197-8211
James V WoodwardDivision of Pulmonology, Phoenix Children's, Phoenix, Arizona, USA.
Scott A OstdiekDivision of Infectious Diseases, Phoenix Children's, Phoenix, Arizona, USA.ORCID 0009-0009-1580-4048
Matthew W SmithDivision of Infectious Diseases, Phoenix Children's, Phoenix, Arizona, USA.ORCID 0009-0007-6497-5877
Victoria L AndersonImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Janine R DaubImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Cindy L PalmerImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Lavenda Chirombo KluczynskiImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Andrew J OlerBioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Magdalena A WalkiewiczCentralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Rajarshi GhoshCentralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Morgan SimilukCentralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-0403-2689
Fariba M DonovanValley Fever Center for Excellence, College of Medicine-Tucson, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-6203-5693
John WittMiraVista Diagnostics, Indianapolis, Indiana, USA.
Nicolas BarrosMiraVista Diagnostics, Indianapolis, Indiana, USA.ORCID 0000-0002-8531-3537
L Joseph WheatMiraVista Diagnostics, Indianapolis, Indiana, USA.
John N GalgianiValley Fever Center for Excellence, College of Medicine-Tucson, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-7882-1883
Alexandra F FreemanImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Amy P HsuImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Christa S ZerbeImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Steven M HollandImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-3207-5464

Funding

Intramural NIH HHS Z99 AI999999National Institute of Allergy and Infectious DiseasesNHLBI NIH HHSNIH
6 · The paper itself

Abstract

Refractory disseminated coccidioidomycosis (DCM) is a severe disease with limited treatment options. This report reviews our own and prior published experiences using adjunctive interferon-γ therapy in refractory DCM, showing overall favorable responses in patients without signal transducer and activator of transcription 1 gain-of-function mutations.

Indexed as

Antifungal AgentsCoccidioidomycosisInterferon-gammaAdultCoccidioidesFemaleHumansMaleMiddle AgedTreatment OutcomeAntifungal AgentsInterferon-gammaantifungal therapiesdisseminated coccidioidomycosisinterferon-γinvasive fungal diseasesignal transducer and activator of transcription 1

Identifiers

PMID40440413
PMCPMC13177199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.