Evidence map›Paper›PMID 40440375›Full record

ArticleScience (New York, N.Y.)2025

Conserved brain-wide emergence of emotional response from sensory experience in humans and mice.

Isaac Kauvar, Ethan B Richman, Tony X Liu, Chelsea Li, Sam Vesuna, Adelaida Chibukhchyan, Lisa Yamada, Adam Fogarty, Ethan Solomon, Eun Young Choi and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. The S1-insula Circuit Differentially Modulates Alcohol Drinking and Aversive Behavior in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Review
  6. Article
  7. Intrinsic space-time couplings governing multi-scale cortical dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Isaac Kauvar *Human Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1336-0721
Ethan B Richman *Human Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8471-266X
Tony X Liu *Human Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9334-8492
Chelsea LiNeurosciences Graduate Program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9464-7002
Sam VesunaHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.
Adelaida ChibukhchyanHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1470-8347
Lisa YamadaHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0003-2454-4830
Adam FogartyHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0009-0007-9124-974X
Ethan SolomonHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0541-7588
Eun Young ChoiHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3226-1486
Leili MortazaviDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9838-4935
Gustavo Chau Loo KungDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Pavithra MukundaHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0009-0003-1020-2650
Cephra RajaDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1758-1246
Dariana Gil-HernándezHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.
Kishandra PatronHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.
Xue ZhangGraduate School of Education, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4279-899X
Jacob BrawerGraduate School of Education, Stanford University, Stanford, CA, USA.
Shenandoah WrobelDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Zoe LuskDepartment of Neurology and Neurological Sciences, Stanford, CA, USA.ORCID 0000-0002-4728-2688
Dian LyuDepartment of Neurology and Neurological Sciences, Stanford, CA, USA.ORCID 0000-0002-9363-7670
Anish MitraHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3362-2274
Laura HackDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA USA.ORCID 0000-0002-2647-4293
Liqun LuoDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5467-9264
Logan GrosenickDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-3216-0319
Peter van RoesselHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9477-604X
Leanne M WilliamsDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA USA.ORCID 0000-0001-9987-7360
Boris D HeifetsHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1474-0379
Jaimie M HendersonDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3276-2267
Jennifer A McNabDepartment of Radiology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1763-0792
Carolyn I RodríguezHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6697-1692
Vivek BuchHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1151-6128
Paul NuyujukianHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7778-5473
Karl DeisserothHuman Neural Circuitry program, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9440-3967

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Training CoreP50DA042012 · NIDA · STANFORD UNIVERSITY · PI Karl A. Deisseroth · 2017 to 2026
$27.1M
A BIOBEHAVIORAL RESEARCH TRAINING PROGRAMT32MH019938 · NIMH · STANFORD UNIVERSITY · PI Corey J Keller, RACHEL MANBER · 1994 to 2026
$9.4M
OPTICAL NEUROMODULATION TECHNOLOGY FOR LONG TIMESCALESR01MH086373 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2010 to 2025
$9.1M
NMDAR Modulation As A Therapeutic Target and Probe of Neural Dysfunction in OCDR01MH105461 · NIMH · STANFORD UNIVERSITY · PI RODRIGUEZ, CAROLYN I · 2015 to 2020
$4.2M
Integration of Diffusion MRI Fiber Tracking and CLARITY 3D Histology for Improved Neurosurgical TargetingR01NS095985 · NINDS · STANFORD UNIVERSITY · PI Jennifer A McNab · 2016 to 2026
$3.8M
Scalable Biomarkers and Generative Digital Twins for Personalized Neurostimulation in DepressionR01MH131534 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LOGAN GROSENICK · 2022 to 2026
$3.2M
Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCDR01MH133553 · NIMH · STANFORD UNIVERSITY · PI Carolyn I Rodriguez · 2023 to 2026
$2.9M
Howard Hughes Medical InstituteNIDA NIH HHS P50 DA042012NIMH NIH HHS R01 MH086373NIMH NIH HHS R01 MH105461NIMH NIH HHS R01 MH131534NIMH NIH HHS R01 MH133553NIMH NIH HHS T32 MH019938NIMH NIH HHS U54 MH091657NINDS NIH HHS R01 NS095985
6 · The paper itself

Abstract

Emotional responses to sensory experience are central to the human condition in health and disease. We hypothesized that principles governing the emergence of emotion from sensation might be discoverable through their conservation across the mammalian lineage. We therefore designed a cross-species neural activity screen, applicable to humans and mice, combining precise affective behavioral measurements, clinical medication administration, and brain-wide intracranial electrophysiology. This screen revealed conserved biphasic dynamics in which emotionally salient sensory signals are swiftly broadcast throughout the brain and followed by a characteristic persistent activity pattern. Medication-based interventions that selectively blocked persistent dynamics while preserving fast broadcast selectively inhibited emotional responses in humans and mice. Mammalian emotion appears to emerge as a specifically distributed neural context, driven by persistent dynamics and shaped by a global intrinsic timescale.

Indexed as

BrainEmotionsSensationAnimalsFemaleHumansMaleMiceMice, Inbred C57BL

Identifiers

PMID40440375
PMCPMC12286656

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.