ReviewCell reports2025
Future threats: Animal orthoflaviviruses that currently infect fewer than 100 people per year.
Review in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- N-linked glycosylation of NS1 protein modulates progeny virion assembly in orthoflaviviruses.PLoS pathogens · 2026Article
- The RNA promoter for pathogenic orthoflaviviruses replication is universal and serves as target for viral inhibition.PLoS pathogens · 2026Article
- Metatranscriptomics profiling reveals rodent- and shrew-borne viral diversity and evolutionary relationships in Guangzhou, China.Virologica Sinica · 2026Article
- Identification of a novel pegivirus in reindeer (Rangifer tarandus valentinae) in Northeastern China.BMC veterinary research · 2025Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
After long periods of evolution, several orthoflaviviruses, including dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, have emerged from nature to infect humans in high numbers. It should be worrisome that there are other orthoflaviviruses now undergoing the same emergence steps, with potential for the same type of outcome as the viruses above. In this review, we document 25 orthoflaviviruses currently infecting fewer than 100 people per year and another 12 for which serological data suggest human exposure, though infection has not been confirmed. The viruses highlighted here have a non-trivial chance of causing human epidemics or pandemics. However, very little is known about the biology of these neglected viruses, and medical countermeasures are lacking for most. Now, before these viruses spill over into the human population, is the time to study the biology of these viruses and to develop or improve PCR- and serology-based diagnostics to enable better monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.