Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Nilam Bhandari *Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
Ashutosh Prince *Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
Mariam R KhanCenter for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
C Alicia TraughberCenter for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
Kalash NeupaneCenter for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
Shuhui W LorkowskiDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Gregory BrubakerDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.ORCID 0000-0002-3882-8415
Elif G ErtugralDepartment of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH 44115.
Chandrasekhar R KothapalliDepartment of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH 44115.ORCID 0000-0001-8450-0640
George R DubyakDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106.ORCID 0000-0001-9720-4226
Jonathan D SmithDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.ORCID 0000-0002-0415-386X
Kailash GulshanCenter for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.ORCID 0000-0002-5598-7370
Funding
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Fabio Cominelli · 2015 to 2026
$15.6M
Phosphatidylinositol Metabolism and Trafficking in Atherosclerosis and InflammationR01HL148158 · NHLBI · CLEVELAND STATE UNIVERSITY · PI Kailash Gulshan · 2020 to 2026
$3.1M
Genetic modifiers of atherosclerosis and macrophage phenotypesR01HL156499 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SMITH, JONATHAN D · 2021 to 2024
$2.5M
American Heart Association (AHA) 23TPA1063910HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL148158NHLBI NIH HHS R01 HL148158NHLBI NIH HHS R01 HL156499NIDDK NIH HHS P30 DK097948
6 · The paper itself
Abstract
Mutations in
Indexed as
Intracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsPhosphatidylinositol 4,5-DiphosphatePyroptosisAdenosine TriphosphatasesAnimalsCell MembraneGasderminsHepatocytesHumansInflammationMacrophagesMiceMice, KnockoutPhospholipid Transfer ProteinsAdenosine TriphosphatasesATP8B1 protein, humanAtp8b1 protein, mouseGasderminsGSDMD protein, humanGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsPhosphatidylinositol 4,5-DiphosphatePhospholipid Transfer ProteinsATP8b1Gasdermin DinflammasomePFIC1PIP2
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D. · full record | OpenQuestion