ArticleJournal of applied clinical medical physics2025
Dosimetric evaluation and clinical application of collimated apertures with proton beam line scanning in stereotactic radiotherapy.
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dosimetric Comparison Between Brass Aperture-Enhanced Proton Pencil Beam Scanning and Photon Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations.International journal of particle therapy · 2026Article
- Early prediction of proton therapy dose distributions and DVHs for hepatocellular carcinoma using contour-based CNN models from diagnostic CT and MRI.Radiation oncology (London, England) · 2025Article
- Dosimetric evaluation and clinical application of collimated apertures with proton beam line scanning in stereotactic radiotherapy.Journal of applied clinical medical physics · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeStereotactic radiotherapy (SRT) is a highly effective treatment with precision for small, localized lesions. Proton therapy, characterized by the Bragg peak, offers superior dose conformity compared to photon-based approaches. However, challenges remain in minimizing lateral penumbra and optimizing dose delivery, particularly for small targets. This study presents the first clinical application of collimated apertures integrated with the proton line scanning technique for proton stereotactic radiotherapy (PSRT). The aim was to evaluate the dosimetric advantages and clinical feasibility of this innovative approach.
methodsOver a 1-year period, 30 patients with small lesions, including choroid melanoma and arteriovenous malformations, were treated using proton line scanning. Two planning strategies were evaluated: uncollimated proton line scanning (UPLS) and collimated proton line scanning (CPLS), incorporating patient-specific apertures. Dosimetric comparisons were conducted using the Homogeneity Index (HI), Paddick Conformity Index (CI
resultsPlans incorporating customized collimated apertures showed significant improvements in dose conformity, with higher CI
conclusionsIntegrating customized collimated apertures with proton beam line scanning is clinically feasible, improving precision, dose conformity, and healthy tissue sparing in PSRT. These findings support adopting this novel approach to advance precision proton therapy for small lesions.
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