Evidence map›Paper›PMID 40439839›Full record

ArticleClinical and experimental nephrology2025

cnm-positive Streptococcus mutans, a major pathogen in dental caries, may exacerbate IgA nephropathy via the tonsils.

Seigo Ito, Taro Misaki, Shuhei Naka, Daiki Matsuoka, Kana Suehara, Yuto Suehiro, Yasuyuki Nagasawa, Ryota Nomura, Michiyo Matsumoto-Nakano, Kazuhiko Nakano

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Article in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seigo ItoDepartment of Internal Medicine, Japan Self-Defense Force Iruma Hospital, Iruma, Saitama, Japan.
Taro MisakiDivision of Nephrology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan. misakitar@gmail.com.ORCID http://orcid.org/0000-0002-0476-2550
Shuhei NakaDepartment of Pediatric Dentistry, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Okayama, Japan.
Daiki MatsuokaDepartment of Pediatric Dentistry, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Okayama, Japan.
Kana SueharaDepartment of Pediatric Dentistry, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Okayama, Japan.
Yuto SuehiroDepartment of Pediatric Dentistry, Division of Oral Infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Yasuyuki NagasawaDepartment of General Internal Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Ryota NomuraDepartment of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan.
Michiyo Matsumoto-NakanoDepartment of Pediatric Dentistry, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Okayama, Japan.
Kazuhiko NakanoDepartment of Pediatric Dentistry, Division of Oral Infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

Funding

Japan Society for the Promotion of Science 21H03149Japan Society for the Promotion of Science 21K08242Japan Society for the Promotion of Science 23K09146
6 · The paper itself

Abstract

backgroundStreptococcus mutans is a major pathogen in dental caries. This organism, which expresses Cnm protein encoded by the cnm gene, has been associated with the pathogenesis of IgA nephropathy (IgAN). Although tonsillectomy is used to treat IgAN, its efficacy is presently unclear in patients with IgAN who harbor cnm-positive S. mutans.

methodsThe presence of cnm-positive S. mutans in saliva specimens from 158 patients with IgAN was determined by polymerase chain reaction assay. The patients were divided according to the results of cnm-positive S. mutans detection and history of tonsillectomy into those who were cnm-positive S. mutans (-), tonsillectomy (-) (group A, n = 57); cnm-positive S. mutans (-), tonsillectomy ( +) (group B, n = 62); cnm-positive S. mutans ( +), tonsillectomy (-) (group C, n = 19); and cnm-positive S. mutans ( +), tonsillectomy ( +) (group D, n = 20). The patients' clinical data were compared between the four groups.

resultsThe proportions of patients with proteinuria > 2 + and an estimated glomerular filtration rate < 60 mL/min/1.73 m

conclusionsThese findings suggest that exacerbation of IgAN by cnm-positive S. mutans is possibly mediated by the tonsils and that tonsillectomy may be particularly effective in patients with IgAN and cnm-positive S. mutans in the oral cavity.

Indexed as

Dental CariesGlomerulonephritis, IGAPalatine TonsilStreptococcal InfectionsStreptococcus mutansAdhesins, BacterialAdultCarrier ProteinsFemaleHumansMaleMiddle AgedProteinuriaSalivaTonsillectomyYoung AdultAdhesins, BacterialCarrier ProteinsCnm protein, Streptococcus mutansCnm-positive S. mutansDental cariesIgA nephropathyTonsillectomy

Identifiers

PMID40439839

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