ArticleThe Journal of general virology2025
An aegerolysin-like protein from Heliothis virescens ascovirus 3h (HvAV-3h) shows immune suppression and antibacterial activity.
Article in The Journal of general virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Pathogens That Rewrite the Rules: Ascoviruses, Elegant Manipulators of Cell Death Pathways and Architects of the Extracellular Viral Paradigm.Pathogens (Basel, Switzerland) · 2025Review
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Authors and funding
7 authors.
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Abstract
Aegerolysins are lipid-binding proteins associated with multiple functions, including membrane pore-formation, insecticidal toxicity and defence against predators. Whilst distributed over the kingdoms of the Tree of Life, ascoviruses are the only representative viruses that encode an aegerolysin-like protein. Ascoviruses are entomopathogenic and possess a large dsDNA genome. The present study aimed to functionally characterize the aegerolysin-like protein of Heliothis virescens ascovirus 3h (HvAV-3h), encoded by ORF85, and to explore its potential roles in the interaction between the ascovirus and its host. Our results demonstrate the importance of this species-specific protein to HvAV-3h replication in host cells.
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