Development of bifunctional fluorescent probes and their application to α-helix labelling.

Laszlo Kondacs, David R Trentham, Thomas Kampourakis, Alexander J A Cobb

Abstract read

In one paragraph

Article in Organic & biomolecular chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Single Fluorogens and Orientation-Localization Microscopy for Quantifying Chemical and Biomolecular Dynamics at the Nanoscale.Accounts of chemical research · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laszlo KondacsDepartment of Chemistry, King's College London, 7 Trinity Street, London SE1 1DB, UK. andre.cobb@kcl.ac.uk.

David R TrenthamRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, UK.

Thomas KampourakisCollege of Medicine, University of Kentucky, 900 S. Limestone Street, William R. Willard Medical Education Building, MN 150, Lexington KY, 40536-0298, USA. thomas.kampourakis@uky.edu.ORCID 0000-0002-8269-1567

Alexander J A CobbDepartment of Chemistry, King's College London, 7 Trinity Street, London SE1 1DB, UK. andre.cobb@kcl.ac.uk.ORCID 0000-0002-3397-9636

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The site selective modification of proteins and peptides is an important venture when it comes to the study of biological systems, such as in the determination of viable pharmacological targets and in the understanding of biomolecular mechanisms. In this paper we report on the development of novel bifunctional probes that allow for the unambiguous site-specific labelling of short peptides for spectroscopic measurements as demonstration of our future intentions to introduce these as functional labels for the study of protein dynamincs

Indexed as

Fluorescent DyesPeptidesFluorescence Resonance Energy TransferMolecular StructureProtein Conformation, alpha-HelicalFluorescent DyesPeptides

Identifiers

PMID40439568

DOI10.1039/d5ob00563a

PMCPMC12121550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.