Evidence map›Paper›PMID 40439513›Full record

ArticleThe Kaohsiung journal of medical sciences2025

Estimation the Maximum Tolerance Activity of Blood by a Simple Algorithm Method in Pediatric Differentiated Thyroid Cancer Patients Treated With Empirical Radioactive Iodine Dosing Based on Risk Stratification.

Yu-Wen Chen, Cheng-Hsun Chuang, Che-Wei Wu, Feng-Yu Chiang, Hon-Man Chen, Kun-Der Lin, Chih-Hung Lin, Yung-Chang Lai, Tzu-Yen Huang

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Article in The Kaohsiung journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yu-Wen ChenDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Cheng-Hsun ChuangDepartment of Otorhinolaryngology-Head and Neck Surgery, International Thyroid Surgery Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-6429-9038
Che-Wei WuDepartment of Otorhinolaryngology-Head and Neck Surgery, International Thyroid Surgery Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Feng-Yu ChiangDepartment of Otolaryngology-Head and Neck Surgery, E-Da Hospital, Kaohsiung, Taiwan.
Hon-Man ChenDepartment of Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kun-Der LinDivision of Endocrinology and Metabolism, Department of Medicine, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chih-Hung LinDivision of Pathology, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yung-Chang LaiDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Tzu-Yen HuangDepartment of Otorhinolaryngology-Head and Neck Surgery, International Thyroid Surgery Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Funding

Kaohsiung Medical University Gangshan HospitalKaohsiung Medical University Hospital, Kaohsiung Medical University KMUH109-9 M44Kaohsiung Medical University Hospital, Kaohsiung Medical University KMUH110-0R51Kaohsiung Medical University Hospital, Kaohsiung Medical University KMUH111-1R48Kaohsiung Medical University Hospital, Kaohsiung Medical University KMUH112-2R51National Science and Technology Council 110-2314-B-037-120National Science and Technology Council 111-2628-B-037-007National Science and Technology Council 112-2314-B-037-034-National Science and Technology Council 113-2314-B-037-035
6 · The paper itself

Abstract

After total thyroidectomy for pediatric differentiated thyroid cancer (DTC), the subsequent radioactive iodine (RAI) treatment is a robust therapy, the dosing of which is a major concern. This study was designed to evaluate the "as high as safe administration" (AHASA) principle of RAI treatment in pediatric DTC patients based on the maximum tolerance activity (MTA) of blood to certify dosimetry via a simple algorithm method. Twenty pediatric DTC patients were enrolled and received RAI treatment empirical dosing based on risk stratification after total thyroidectomy. The MTA concentration in the blood was estimated by the modified Hänscheid equation. About 6 (30%) patients had tumors larger than 4 cm, 10 (50%) patients had lateral cervical lymph node metastasis, and 4 (20%) patients had recurrent/persistent thyroid cancer and received more than two RAIs. Five (25%) pediatric patients who had higher serum thyroglobulin antibodies levels at initial diagnosis exhibited aggressive clinical manifestations. Body weight-based doses showed wide variability, and the Dutch recommended dose showed underdosing. In addition, lower body weight was associated with a significantly higher blood absorption dose (R

Indexed as

AlgorithmsIodine RadioisotopesThyroid NeoplasmsAdolescentChildChild, PreschoolFemaleHumansMaleRisk AssessmentThyroidectomyIodine Radioisotopesas high as safe administration (AHASA) principlemaximum tolerance activity (MTA)pediatric differentiated thyroid cancer (DTC)radioactive iodine (RAI) treatmentsimple method algorithm

Identifiers

PMID40439513
PMCPMC12520466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.