Evidence map›Paper›PMID 40439512›Full record

ReviewAmerican journal of respiratory cell and molecular biology2025

Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases.

Sushrut D Shah, Deepak A Deshpande

Abstract readReview
In one paragraph

Review in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Agonist-specific conformational dynamics at the βBritish journal of pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sushrut D ShahCenter for Translational Medicine, Jane and Leonard Korman Lung Center, Thomas Jefferson University, Philadelphia, Pennsylvania.ORCID 0000-0002-4201-6532
Deepak A DeshpandeCenter for Translational Medicine, Jane and Leonard Korman Lung Center, Thomas Jefferson University, Philadelphia, Pennsylvania.ORCID 0000-0002-6187-5332

Funding

Diacylglycerol kinase in airway smooth muscle functionsR01HL146645 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A, KAMBAYASHI, TAKU · 2019 to 2024
$2.8M
Allosteric modulation of beta2- adrenoceptors in the treatment of asthmaR01HL173113 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI Deepak A Deshpande · 2024 to 2026
$1.7M
Optimizing function-selective ERK1/2 inhibitors for reducing AP-1-mediated airway pathology in asthma.R61HL168723 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI DESHPANDE, DEEPAK A, SHAPIRO, PAUL S · 2023 to 2024
$1.0M
Optimizing function-selective ERK1/2 inhibitors for reducing AP-1-mediated airway pathology in asthma.R33HL168723 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI DESHPANDE, DEEPAK A, SHAPIRO, PAUL S · 2025 to 2025
$362k
American Heart Association 24PRE1183692NHLBI NIH HHS R01 HL146645NHLBI NIH HHS R01 HL173113NHLBI NIH HHS R33 HL168723NHLBI NIH HHS R61 HL168723
6 · The paper itself

Abstract

The obstructive lung diseases (OLDs), such as asthma and chronic obstructive pulmonary disease (COPD) are characterized by bronchoconstriction and difficulty in breathing. β

Indexed as

Adrenergic beta-2 Receptor AgonistsAdrenergic beta-AgonistsAsthmaLung Diseases, ObstructivePulmonary Disease, Chronic ObstructiveAllosteric RegulationAnimalsDrug DevelopmentHumansReceptors, Adrenergic, beta-2Adrenergic beta-2 Receptor AgonistsAdrenergic beta-AgonistsReceptors, Adrenergic, beta-2adrenergic receptorallosteric modulatorbiased agonismbiased signalingbronchodilatorβ-agonists

Identifiers

PMID40439512
PMCPMC12499927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.