ArticleEmerging infectious diseases2025
High Genetic Diversity of Histoplasma in the Amazon Basin, 2006-2017.
Article in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The dynamics of transposable element content in the genome of the human pathogen Histoplasma.Fungal genetics and biology : FG & B · 2026Article
- New 2030 Global Targets for Histoplasmosis from International Society for Human and Animal Mycology (ISHAM) 2025 Histoplasmosis Working Group.Emerging infectious diseases · 2026Article
- Genomic epidemiology ofmBio · 2025Article
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Authors and funding
17 authors.
Funding
Abstract
Histoplasmosis is one of the most common pulmonary mycosis diseases in the world. Genome sequencing has revealed that Histoplasma, the cause of histoplasmosis, is composed of several phylogenetic species. The genetic diversity of the pathogen remains largely unknown, especially in the tropics. We sequenced the genomes of 91 Histoplasma isolates from the Amazon basin of South America and used phylogenomics and population genetic evidence to measure the genetic variation of the genus in South America. We report a previously unidentified clade of Histoplasma endemic to the Amazon basin. The lineage is widespread across the continent and contains 5 lineages that are sufficiently differentiated to be considered phylogenetic species. We found the geographic range of those lineages is largely but not completely overlapping. Finally, we found that the patient median age and sex ratio differs among species, suggesting differences in the epidemiology of histoplasmosis caused by each Histoplasma lineage.
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