Evidence map›Paper›PMID 40439377›Full record

Trial reportAsian Pacific journal of cancer prevention : APJCP2025

Effect of Structured Exercise-based rehabilitation on Sarcopenia and Quality of life among Head and Neck Cancer Patients Undergoing Chemo-radiotherapy: A Randomized Controlled Trial.

Cherishma D'Silva, Vijith Shetty, Donald Fernandes, Baeyen Jean-Pierre, Suchetha Kumari N, Saumya Srivastava, Stephen Rajan Samuel

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Cherishma D'SilvaFather Muller College of Physiotherapy, Mangalore, India.
Vijith ShettyDepartment of Medical Oncology, KS Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, India.
Donald FernandesDepartment of Radiation Oncology Father Muller Medical College, Mangalore, India.
Baeyen Jean-PierreTHIM Internationale Hochschule für Physiotherapie, Landquart, Switzerland.
Suchetha Kumari NNitte Institute of Physiotherapy, NITTE (Deemed to be University), Mangalore, India.
Saumya SrivastavaBiological, Physical and Exercise Sciences Department, Mount Vernon Nazarene University, Ohio, United States of America.
Stephen Rajan SamuelDepartment of Biochemistry, KS Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia is considered an independent prognostic factor for overall survival and performance status in head and neck cancer (HNC) receiving chemo-radiotherapy (CRT). CRT is known to cause sleep disturbances, increased pain perception, depression leading to reduced quality of life (QOL). Exercise-based rehabilitation has emerged as a promising strategy for improving outcomes in HNC. Our study aimed to evaluate effect of exercise on sarcopenia and QOL in patients with HNC receiving CRT. METHODOLOGY: Seventy HNC patients, aged 40-70 years TNM stage III- IVb receiving CRT, were randomized into two groups and received intervention for seven weeks. Intervention Group, IG (n=40) received combined aerobic and resistance training according to the ACSM guidelines. Control Group, CG (n=40) were advised to walk according to the NCCN guidelines. Sarcopenia was assessed using Bio Impedance Analyser (BIA), muscle strength using JAMAR hand dynamometer and QOL by FACT H&N on pre CRT day 1 and post 7 weeks. Wilcoxon signed-rank test and Mann-Whitney U test were used to assess within-group differences and  between-group comparisons respectively.

results80 participants with a mean age of 58.44 ±3.75 years were included. IG showed a smaller decrease in total skeletal muscle mass compared to CG with IGs total skeletal muscle mass decreasing from 35 to 30 and CGs muscle mass decreasing from 40 to 21 (p<0.001). QOL showed significant improvement in CG from 66 to 61 (p < 0.001). In contrast, IGs quality of life saw a minor, non-significant change from 62 to 61.

conclusionSarcopenia was lesser in IG compared to CG, highlighting the favourable impact of resistance training and its inclusion in the HNC rehabilitation. However, CG demonstrated significant improvements in quality of life as compared to IG suggesting that quality of life is a multifaceted construct that may not be directly correlated with physical improvements alone.

Indexed as

ChemoradiotherapyExercise TherapyHead and Neck NeoplasmsQuality of LifeSarcopeniaAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedMuscle StrengthPrognosisResistance Trainingchemoradiation therapyexercise-based rehabilitationhead and neck cancerQuality of Lifesarcopenia

Identifiers

PMID40439377
PMCPMC12290174

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.