Evidence map›Paper›PMID 40439349›Full record

ArticleEmerging infectious diseases2025

Multicenter Retrospective Study of Spiroplasma ixodetis Infantile Cataract in 8 Countries in Europe.

Luc Van Os, Nathalie Cassoux, Symira Cholidis, Pascal Dureau, Navid Farassat, Fabienne Catherine Fierz, Ebba Ghyczy, Elena-Cristina Nitulescu, Eva Stifter, Marie-José Tassignon and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A human-associatediScience · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Luc Van Os
Nathalie Cassoux
Symira Cholidis
Pascal Dureau
Navid Farassat
Fabienne Catherine Fierz
Ebba Ghyczy
Elena-Cristina Nitulescu
Eva Stifter
Marie-José Tassignon
Anne Le Flèche-Matéos
Birgit Lorenz
Spiroplasma Infantile Cataract Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spiroplasma ixodetis has been reported to cause the rare combination of cataract and uveitis in infants. Through a retrospective analysis of available literature and additional unpublished cases, we identified 28 eyes from 18 infants from 8 countries in Europe with cataracts and intraocular inflammation. The cataracts were bilateral in 55.6%, unilateral in 44.4%, and progressive in 46.4% of patients. Granulomatous anterior uveitis was found in all infants. Presence of S. ixodetis was supported by PCR (positive in 89.3% of eyes tested), transmission electron microscopy (positive in 90% of eyes tested), or culture of aspirated lens material (positive in 87.5% of eyes tested). Treatment with macrolide antimicrobial drugs, corticosteroids, and lensectomy appeared to be effective. Two patients had a recurrence of the uveitis after lens extraction and needed prolonged treatment. To increase awareness of S. ixodetis, we suggest its inclusion with the organisms of the TORCH acronym.

Indexed as

CataractGram-Negative Bacterial InfectionsAnti-Bacterial AgentsEuropeFemaleHumansInfantMaleRetrospective StudiesAnti-Bacterial AgentsAustriabacteriaBelgiumCataractEuropeFranceGermanyinfantsLuxembourgNorwayRomaniaSpiroplasma ixodetisSwitzerlandthe NetherlandsTORCHESuveitis

Identifiers

PMID40439349
PMCPMC12123929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.