Can autophagy enhance crop resilience to environmental stress?

Climate change imposes abiotic stress on plants, significantly threatening global agriculture and food security. This indicates a need to apply our understanding of plant stress responses to improve crop resilience to these threats. Stress damages critical cellular components such as mitochondria, chloroplasts and the endoplasmic reticulum. Left unmitigated, abiotic stress can lead to cell death, which typically decreases overall plant health and productivity. Autophagy is a catabolic process that maintains cellular homeostasis by degrading and recycling damaged and dysfunctional cell components and organelles. Importantly, autophagy promotes plant tolerance to a wide range of environmental stresses, and manipulation of autophagy may lead to improved stress resilience in crops. Here, we discuss recent advances in our understanding of how autophagy affects abiotic stress resistance. We discuss the function of autophagy in different abiotic stresses (including nutrient stress, salt stress, drought, heat, cold, hypoxia, light stress and combined stresses) and provide insights from functional and genome-wide transcriptomic studies. We also evaluate the potential to enhance crop survival and productivity in suboptimal environmental conditions by activating autophagy, emphasizing the importance of targeted manipulation of key genes involved in the autophagy pathway.This article is part of the theme issue 'Crops under stress: can we mitigate the impacts of climate change on agriculture and launch the 'Resilience Revolution'?'.