Evidence map›Paper›PMID 40439285›Full record

ReviewJournal of cellular biochemistry2025

Energy-Dependent Phosphate and Acid Transport for Bone Formation and Resorption.

Irina L Tourkova, Deborah J Nelson, Paul H Schlesinger, Harry C Blair

Abstract readReview
In one paragraph

Review in Journal of cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Glucose metabolism in osteoporosis: A potential therapeutic target (Review).International journal of molecular medicine · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Irina L TourkovaResearch Service, VA Medical Centre, Pittsburgh, PA, USA.ORCID 0000-0002-6511-6616
Deborah J NelsonDept of Neurobiology, Pharmacology & Physiology, University of Chicago, Chicago, IL, USA.
Paul H SchlesingerDepartment of Cell Biology, Washington University, St. Louis, MO, USA.
Harry C BlairResearch Service, VA Medical Centre, Pittsburgh, PA, USA.ORCID 0000-0002-1152-3718

Funding

Epithelial Osteoblast Function: The Role of Acid TransportR01AR076146 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BLAIR, HARRY COLBERT, NELSON, DEBORAH J. · 2020 to 2024
$2.6M
NIAMS NIH HHS R01 AR076146VA BX002490-06A1
6 · The paper itself

Abstract

Bone formation and resorption are mediated by an epithelial-like cell layer on bone. Formation or resorption requires active transport that depends on aerobic glycolysis, ATP, and acid transport. Metabolic activity of bone cells during matrix formation or removal is so high that the cells autolyze rapidly after cell death. Mineralization of bone matrix uses import of phosphate by sodium-phosphate cotransport, supported by the Na

Indexed as

Bone and BonesBone ResorptionOsteogenesisPhosphatesProton PumpsAnimalsCalciumHumansPhosphoric Diester HydrolasesCalciumPhosphatesPhosphoric Diester HydrolasesProton PumpsBone mineralizationNa+/PO42‐ transportOsteoblastOsteoclastV‐ATPase

Identifiers

PMID40439285
PMCPMC12121336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.