Evidence map›Paper›PMID 40439260›Full record

SynthesisPhysiotherapy research international : the journal for researchers and clinicians in physical therapy2025

The Effectiveness of Mulligan's Techniques in Non-Specific Neck Pain: A Systematic Review and Meta-Analysis.

Jordana Barbosa-Silva, Alexandre Luc, Ana Izabela Sobral de Oliveira-Souza, Raphael Martins de Abreu, Jakelline Cipriano, Marine de Schaetzen, Laurent Pitance, Susan Armijo-Olivo

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Physiotherapy research international : the journal for researchers and clinicians in physical therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07725861 (Effects of Strain Counter Strain With and Without Sustained Natural Aphophyseal Glide on Pain Range Of Motion ,Craniovertebral Angle and Disability in Patients With Non Specific Neck Pain), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07725861 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Strain Counter Strain With and Without Sustained Natural Aphophyseal Glide on Pain Range Of Motion ,Craniovertebral Angle and Disability in Patients With Non Specific Neck Pain

TypeinterventionalSponsorRiphah International UniversityRan2026 to 2026Enrolled68ConditionsCervical PainArmsStrain Counterstrain + SNAG with Common Treatment, Strain Counterstain (SCS) only
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jordana Barbosa-SilvaPhysical Therapy Department, Federal University of São Carlos, São Carlos, Brazil.ORCID https://orcid.org/0000-0001-9867-3788
Alexandre LucNeuro Musculo Skeletal Lab, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.
Ana Izabela Sobral de Oliveira-SouzaFaculty of Business and Social Sciences, University of Applied Sciences, Osnabrück, Germany.
Raphael Martins de AbreuDepartment of Physiotherapy, LUNEX University, International University of Health, Differdange, Luxembourg.
Jakelline CiprianoUniversity of Pernambuco, Recife, Brazil.
Marine de SchaetzenNeuro Musculo Skeletal Lab, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.
Laurent PitanceNeuro Musculo Skeletal Lab, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.
Susan Armijo-OlivoFaculty of Business and Social Sciences, University of Applied Sciences, Osnabrück, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeMulligan's techniques, such as Sustained Natural Apophyseal Glides (SNAGs) and Natural Apophyseal Glides (NAGs), are commonly applied by physiotherapists when treating patients with non-specific neck pain (NP). However, there has been no comprehensive synthesis of their effects in NP. This review aimed to assess the effectiveness of Mulligan's techniques in reducing pain, improving disability, and enhancing cervical range of motion (CROM) in adults with acute, subacute, or chronic NP.

methodsA systematic review with meta-analysis was conducted on randomized controlled trials (RCTs) comparing Mulligan's techniques with other interventions in adults with NP. Two reviewers independently conducted study selection, data extraction, and risk of bias (RoB) assessment. Meta-analyses were performed when clinical homogeneity was present; otherwise, a narrative synthesis was used. Certainty of evidence was rated using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.

resultsThirty-three studies were included. For acute and mixed (acute/subacute/chronic) NP, Mulligan's techniques were no more effective than other interventions for pain reduction, disability improvement, or CROM enhancement. However, in patients with chronic or uncertain chronicity NP, SNAGs combined with other interventions demonstrated superior outcomes-both statistically and sometimes clinically-compared to certain treatments like exercises and muscle-energy techniques, for reducing pain and disability and improving CROM. The certainty of evidence was rated very low. DISCUSSION: Mulligan's techniques appear to be safe, simple, and potentially beneficial for managing mixed or chronic NP when combined with other interventions, presenting results that may be comparable or occasionally superior to other standard techniques. IMPLICATIONS FOR PHYSIOTHERAPY PRACTICE: Physiotherapists may consider incorporating Mulligan's techniques, especially SNAGs, within broader NP treatment strategies, as they offer a feasible, low-risk option for improving patient outcomes, particularly for chronic NP cases when used alongside other therapies.

Indexed as

Neck PainPhysical Therapy ModalitiesHumansRandomized Controlled Trials as TopicRange of Motion, ArticularTreatment Outcomemusculoskeletal manipulationsneck painphysical therapy modalitiesrandomized controlled trialssystematic review

Identifiers

PMID40439260
PMCPMC12121345

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.