Evidence map›Paper›PMID 40439170›Full record

ArticleJournal of the American Heart Association2025

Differential Characteristics and Outcomes of Urgent/Emergent Versus Elective Aortic Valve Replacement.

Joseph E Ebinger, Aakriti Gupta, Tzu Yu Huang, Marcella A Kelley, Christin Thompson, Maria Platanis, Susan Cheng

Abstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph E EbingerDepartment of Cardiology Smidt Heart Institute, Cedars-Sinai Medical Center Los Angeles CA USA.ORCID 0000-0002-0587-1572
Aakriti GuptaDepartment of Cardiology Smidt Heart Institute, Cedars-Sinai Medical Center Los Angeles CA USA.ORCID 0000-0001-9103-9872
Tzu Yu HuangDepartment of Cardiology Smidt Heart Institute, Cedars-Sinai Medical Center Los Angeles CA USA.ORCID 0009-0000-8793-847X
Marcella A KelleyEdwards Lifesciences Irvine CA USA.
Christin ThompsonEdwards Lifesciences Irvine CA USA.ORCID 0000-0002-4713-4730
Maria PlatanisEdwards Lifesciences Irvine CA USA.ORCID 0009-0006-7549-9127
Susan ChengDepartment of Cardiology Smidt Heart Institute, Cedars-Sinai Medical Center Los Angeles CA USA.ORCID 0000-0002-4977-036X

Funding

Implementation Science to Improve Cardiovascular Health: Leveraging EHR Systems to Advance Care of Resistant HypertensionK23HL153888 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI EBINGER, JOSEPH · 2020 to 2024
$929k
NHLBI NIH HHS K23 HL153888
6 · The paper itself

Abstract

backgroundDespite the slowly progressive nature of aortic stenosis, a proportion of aortic valve replacements (AVRs) still occur on an urgent/emergent basis. We sought to characterize the predictors, outcomes, and potential opportunities to prevent urgent/emergent AVRs.

methodsWe analyzed Medicare data to identify patients undergoing AVRs from 2017 to 2022. We used multivariable regression to identify factors associated with nonelective AVRs; we also examined the association of nonelective AVRs with clinical outcomes and health care costs.

resultsIn total, 15 305 patients (16% urgent/emergent) underwent AVR during the study period. Compared with patients undergoing elective AVRs, those receiving urgent/emergent AVRs were more frequently of Black race or Hispanic ethnicity, and less likely to have received a diagnosis of aortic stenosis, despite 91.7% having seen a cardiologist or primary care provider in the prior year. In multivariable-adjusted analyses, dual Medicare-Medicaid enrollment, male sex, and recent heart failure hospitalization were associated with increased risk for urgent/emergent AVR; conversely, recent aortic stenosis diagnosis and cardiologist visit were associated with lower odds of urgent/emergent AVR. In turn, urgent/emergent compared with elective AVR increased risk for in-hospital death, intensive care unit admission, and discharge to a facility versus home, in addition to longer lengths of stay and higher health care costs.

conclusionsUrgent/emergent AVR occurs more frequently among Black, Hispanic, and dual Medicare-Medicaid-eligible patients. Nonelective AVR is also associated with worse hospital outcomes as well as greater health care costs. Importantly, variable timing in diagnosis of aortic stenosis appears to be a key determinant; thus, augmented screening efforts may improve outcomes and reduce disparities.

Indexed as

Aortic ValveAortic Valve StenosisElective Surgical ProceduresHeart Valve Prosthesis ImplantationAgedAged, 80 and overEmergenciesFemaleHumansMaleMedicareRetrospective StudiesRisk FactorsTreatment OutcomeUnited Statesaortic valve replacementcardiovascular outcomesdisparitiesMedicare

Identifiers

PMID40439170
PMCPMC12229216

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.