Evidence map›Paper›PMID 40439163›Full record

ArticleJournal of extracellular vesicles2025

Glutamatergic Regulation of miRNA-Containing Intraluminal Vesicle Trafficking and Extracellular Vesicle Secretion From Cortical Neurons.

Marcela Bertolio, Qiyi Li, Francesca E Mowry, Kathryn E Reynolds, Rashed Alananzeh, Haichao Wei, Kyoeun Keum, Rachel Jarvis, Jiaqian Wu, Yongjie Yang

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Rab27: Molecular switch of tumor exosome secretion (Review).International journal of molecular medicine · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcela BertolioDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Qiyi LiDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Francesca E MowryDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Kathryn E ReynoldsDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7203-2827
Rashed AlananzehDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Haichao WeiDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
Kyoeun KeumDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Rachel JarvisDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Jiaqian WuDepartment of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
Yongjie YangDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-0318-8224

Funding

CNS Exosomes-Mediated Adaptive Immunity in Alzheimer's Disease (AD)R01AG078728 · NIA · TUFTS UNIVERSITY BOSTON · PI ALEXEI DEGTEREV, Yongjie Yang · 2022 to 2026
$4.4M
Identifying Novel Molecular Targets for Chronic SCIR01NS088353 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JIaqian Wu-Huber · 2015 to 2026
$4.0M
Astrolglia-Mediated Pathogenic Mechanisms in Fragile X Syndrome (FXS)R01MH106490 · NIMH · TUFTS UNIVERSITY BOSTON · PI YANG, YONGJIE · 2016 to 2025
$3.3M
Exosomal miRNA in neuron to astroglial communication in the CNSR01NS118747 · NINDS · TUFTS UNIVERSITY BOSTON · PI YANG, YONGJIE · 2020 to 2024
$2.2M
Dysfunctional Astroglial Exosome to (motor) Neuron Axon Signaling in ALSR01NS125490 · NINDS · TUFTS UNIVERSITY BOSTON · PI Yongjie Yang · 2022 to 2026
$2.1M
NIA NIH HHS R01 AG078728NIH HHS R01AG078728NIH HHS R01NS118747NIH HHS R01NS125490NIMH NIH HHS R01 MH106490NINDS NIH HHS R01 NS088353NINDS NIH HHS R01 NS118747NINDS NIH HHS R01 NS125490
6 · The paper itself

Abstract

Neuronal extracellular vesicles (microvesicles and exosomes) are emerging secreted vesicular signals that play important roles in the CNS. Currently, little is known about how glutamatergic signalling affects the subcellular localisation of exosome precursor intraluminal vesicles (ILVs), microRNA (miR) packaging into ILVs and in vivo spreading of neuronal EVs. By selectively labelling ILVs and exosomes (but not plasma membrane-derived MVs) with GFP-tagged human CD63 (hCD63-GFP) in cortical neurons, we found that glutamate stimulation significantly redistributes subcellular localisation of hCD63-GFP

Indexed as

Cerebral CortexExtracellular VesiclesGlutamic AcidMicroRNAsNeuronsAnimalsCells, CulturedExosomesHumansMiceTetraspanin 30Glutamic AcidMicroRNAsTetraspanin 30CD63extracellular vesiclesglutamate stimulationintraluminal vesicles (ILVs)microRNA

Identifiers

PMID40439163
PMCPMC12120566

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.