Evidence map›Paper›PMID 40439124›Full record

Observational studyThe Journal of infectious diseases2025

HIV Superinfection in Kidney Transplant Recipients With HIV Who Received Organs From Donors With HIV.

Gracie M Rozek, Ping Yang, Yolanda Eby, Sarah E Benner, Craig Martens, Feben Habtehyimer, Maggie Chahoud, Diane Brown, Niraj M Desai, Sander Florman and 14 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Donor-derived viral infections: the usual suspects and the new kids on the block.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Gracie M RozekDepartment of Medicine.
Ping YangDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore.
Yolanda EbyDepartment of Medicine.
Sarah E BennerDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore.ORCID 0000-0002-8336-2976
Craig MartensNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-8112-2234
Feben HabtehyimerDepartment of Medicine.
Maggie ChahoudDepartment of Medicine.ORCID 0000-0001-5190-2985
Diane BrownDepartment of Medicine.
Niraj M DesaiDepartment of Surgery, Northwell Transplant Institute, Manhasset.
Sander FlormanDepartment of Surgery, Recanati/Miller Transplantation Institute.ORCID 0000-0002-1635-9136
Meenakshi M RanaDepartment of Medicine, Icahn School of Medicine at Mount Sinai.
Marcus R PereiraDepartment of Medicine, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0002-9214-9122
Jonathan HandDepartment of Medicine, Ochsner Health, New Orleans, Louisiana.ORCID 0000-0002-5752-9576
Sapna A MehtaDepartment of Medicine, NYU Langone Transplant Institute, New York, New York.ORCID 0000-0002-5588-905X
Joanna SchaenmanDepartment of Medicine, University of California Los Angeles.
Carlos A Q SantosDivision of Infectious Diseases, Rush University Medical Center, Chicago, Illinois.ORCID 0000-0002-6224-0371
Saima AslamDepartment of Medicine, University of California San Diego.
Nahel EliasDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston.ORCID 0000-0001-6466-7347
Jonah OdimNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Megan MorsheimerNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-8237-3094
Dorry L SegevDepartment of Medicine, NYU Langone Transplant Institute, New York, New York.ORCID 0000-0002-1924-4801
Christine M DurandDepartment of Medicine.ORCID 0000-0003-2605-9257
Aaron A R TobianDepartment of Medicine.ORCID 0000-0002-0517-3766
Andrew D ReddDepartment of Medicine.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
HOPE in Action: A Clinical Trial of HIV-to-HIV Liver TransplantationU01AI138897 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2018 to 2026
$25.5M
Kidney Transplantation from Donors with HIV: Impact on Rejection and Long-term OutcomesU01AI177211 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2023 to 2026
$6.9M
Unlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3M
T-cell depletion and maintenance of the HIV-1 latent reservoir in distinct tissue compartmentsR01DK131926 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Melissa Laird Smith, AARON A TOBIAN · 2022 to 2026
$3.6M
NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI120938NIDDK NIH HHS R01 DK131926NIH HHS R01AI20938NIH HHS R01DK131926NIH HHS U01 AI138897NIH HHS U01AI177211
6 · The paper itself

Abstract

Transplantation of kidneys from donors with HIV to recipients with HIV (HIV D+/R+) has been shown to be safe and effective, but there is a unique risk of donor-derived HIV superinfection (HIV-SI) in these recipients. Recipients from a multicenter observational HIV D+/R+ study were examined for HIV-SI by site-directed next-generation sequencing (Illumina). Eighteen recipients of HIV D+/R+ kidney transplants had baseline and follow-up samples that successfully amplified. One recipient was confirmed to have experienced donor-derived HIV-SI at week 26 but did not experience any clinically significant changes. HIV-SI in recipients of HIV D+/R+ transplants is rare, and the clinical ramifications appear negligible.

Indexed as

HIV InfectionsKidney TransplantationSuperinfectionTissue DonorsTransplant RecipientsAdultFemaleHigh-Throughput Nucleotide SequencingHIV-1HumansMaleMiddle AgedHIVHOPE Actkidneyorgan transplantationsuperinfection

Identifiers

PMID40439124
PMCPMC12349943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.