Evidence map›Paper›PMID 40439121›Full record

ArticleJournal of diabetes investigation2025

Association of the IL-6R rs2228145 polymorphism with diabetic nephropathy: A case-control study.

Pavla Izakovicova, Simona Slezakova, Tereza Deissova, Hana Poskerova, Petra Borilova Linhartova, Ladislav Dusek, Katerina Kankova, Lydie Izakovicova Holla

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In one paragraph

Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Pavla Izakovicova *Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Simona Slezakova *Clinic of Stomatology, Faculty of Medicine, Institution Shared with St. Anne's University Hospital, Masaryk University, Brno, Czech Republic.
Tereza DeissovaDepartment of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Hana PoskerovaClinic of Stomatology, Faculty of Medicine, Institution Shared with St. Anne's University Hospital, Masaryk University, Brno, Czech Republic.
Petra Borilova LinhartovaClinic of Stomatology, Faculty of Medicine, Institution Shared with St. Anne's University Hospital, Masaryk University, Brno, Czech Republic.
Ladislav DusekInstitute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Katerina KankovaDepartment of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Lydie Izakovicova HollaClinic of Stomatology, Faculty of Medicine, Institution Shared with St. Anne's University Hospital, Masaryk University, Brno, Czech Republic.ORCID https://orcid.org/0000-0002-7610-8929

Funding

European Union's Horizon 2020 857560Lékařská fakulta, Masarykova univerzita MUNI/A/1768/2024Ministerstvo Školství, Mládeže a Tělovýchovy LM2023069National Institute for Research of Metabolic and Cardiovascular Disease project LX22NPO5104
6 · The paper itself

Abstract

introductionThe pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin-6 (IL-6); IL-6 triggers intracellular pathways through interaction with the IL-6 receptor (IL-6R). This study aimed to determine the association of single nucleotide polymorphisms (SNPs) IL-6 -597G/A (rs1800797), -572G/C (rs1800796), -174G/C (rs1800795), its receptor (IL-6R) Asp358Ala (+48892A/C, rs2228145) and DM or its complications in the Czech population. MATERIALS AND

methodsIn total, 669 subjects participated in this case-control study, including 167 controls, 119 patients with type 1 DM (T1DM), and 383 patients with type 2 DM (T2DM). The subjects were monitored for glycemia, glycated hemoglobin, lipid profile, glomerular filtration rate (GFR), and common complications, such as diabetic nephropathy (DN), retinopathy (DR), (poly)neuropathy (DPN), and periodontitis (P).

resultsFrequencies of the IL-6 and IL-6R alleles or genotypes, and IL-6 haplotypes were similar between the controls and the patients with T1DM or T2DM (P > 0.05). However, lower values of GFR were observed in diabetic patients with IL-6 -174CC homozygotes compared to other (CG and GG) genotypes (P ≤ 0.05). In addition, the IL-6R Asp358Ala variant was associated with DN (P = 0.031, OR = 1.74, 95% CI: 1.05-2.89). After subclassification according to the type of DM, the significant association of the IL-6R polymorphism with DN was only found in T1DM (P = 0.013, OR = 2.90, 95% CI: 1.25-6.71).

conclusionsThis study implies a significant relationship between the IL-6R Asp358Ala polymorphism and DN in Czech T1DM patients.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NephropathiesPolymorphism, Single NucleotideReceptors, Interleukin-6AdultAgedCase-Control StudiesCzech RepublicFemaleGenetic Predisposition to DiseaseGenotypeHumansInterleukin-6MaleMiddle AgedIL6 protein, humanIL6R protein, humanInterleukin-6Receptors, Interleukin-6Diabetic nephropathyIL‐6Polymorphisms

Identifiers

PMID40439121
PMCPMC12315239

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.