Evidence map›Paper›PMID 40439003›Full record

ArticleeLife2025

Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences.

Elise Miedlar, Grace E Hamilton, Samuel R Witus, Sara J Gonske, Michael Riffle, Alex Zelter, Rachel E Klevit, Charles L Asbury, Yoana N Dimitrova, Trisha N Davis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structure and function of the centromere and inner kinetochore.Nature reviews. Molecular cell biology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Elise MiedlarDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID https://orcid.org/0009-0009-8209-5210
Grace E HamiltonDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-0522-0702
Samuel R WitusDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0003-1907-8484
Sara J GonskeDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID https://orcid.org/0009-0003-5491-9469
Michael RiffleDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0003-1633-8607
Alex ZelterDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-5331-0577
Rachel E KlevitDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-3476-969X
Charles L AsburyDepartment of Neurobiology and Biophysics, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-0143-5394
Yoana N DimitrovaDepartment of Structural Biology, Genentech, Inc, South San Francisco, United States.
Trisha N DavisDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0003-4797-3152

Funding

Reconstitution and biophysical study of chromosome segregation machineryR35GM134842 · NIGMS · UNIVERSITY OF WASHINGTON · PI Charles L Asbury · 2020 to 2026
$4.7M
Molecular Analysis of Chromosome SegregationR35GM130293 · NIGMS · UNIVERSITY OF WASHINGTON · PI DAVIS, TRISHA N. · 2019 to 2023
$3.5M
Defining the role of BARD1 in nucleosomal ubiquitylationR01CA260834 · NCI · UNIVERSITY OF WASHINGTON · PI BRZOVIC, PETER S, KLEVIT, RACHEL E · 2021 to 2025
$2.7M
NCI NIH HHS R01 CA260834NCI NIH HHS R01CA260834NIGMS NIH HHS R35 GM130293NIGMS NIH HHS R35GM130293NIGMS NIH HHS R35 GM134842NIGMS NIH HHS R35GM134842
6 · The paper itself

Abstract

Previously, we reconstituted a minimal functional kinetochore from recombinant

Indexed as

CentromereDNA, FungalKinetochoresSaccharomyces cerevisiaeChromosomal Proteins, Non-HistoneDNA-Binding ProteinsMicrotubulesNucleosomesSaccharomyces cerevisiae ProteinsChromosomal Proteins, Non-HistoneCSE4 protein, S cerevisiaeDNA-Binding ProteinsDNA, FungalNucleosomesSaccharomyces cerevisiae Proteinscell biologycentromerekinetochoremicrotubulemitosisnucleosomeS. cerevisiaetension

Identifiers

PMID40439003
PMCPMC12121997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.