Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Roland VeressDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).ORCID 0000-0001-8733-7228
Radmila TerentyevaDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).ORCID 0000-0002-0133-3515
Andriy E BelevychDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).ORCID 0000-0002-1272-5784
Fruzsina PergerDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).
Zuzana NichtovaDepartment of Pathology, Anatomy and Cell Biology, MitoCare Center, Thomas Jefferson University, Philadelphia, PA (Z.N., G.C.).
Anastasia PokrassDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).
Yujia ChengFood Science and Human Nutrition Department, University of Florida, Gainesville (Y.C., B.L.).ORCID 0009-0001-4284-5285
Snizhana ChornaDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).ORCID 0009-0007-0608-7193
Isabelle DeschenesDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).ORCID 0000-0002-1812-7267
Sandor GyorkeDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).
Bjorn C KnollmannDepartment of Medicine, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical School, Nashville, TN (B.C.K.).ORCID 0000-0003-4956-9735
Richard T ClementsDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island College of Pharmacy, Kingston (R.T.C.).
Harpreet SinghDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).ORCID 0000-0002-6135-1897
Bin LiuFood Science and Human Nutrition Department, University of Florida, Gainesville (Y.C., B.L.).ORCID 0000-0003-4797-8105
Gyorgy CsordasDepartment of Pathology, Anatomy and Cell Biology, MitoCare Center, Thomas Jefferson University, Philadelphia, PA (Z.N., G.C.).ORCID 0000-0003-3156-1460
Shanna HamiltonDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson (S.H.).ORCID 0000-0003-1016-4706
Dmitry TerentyevDepartment of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).ORCID 0000-0002-9530-7384
Funding
CONTROLLED AND UNCONTROLLABLE CALCIUM RELEASE IN HEARTR01HL063043 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI Sandor Gyorke · 1999 to 2026
$8.6M
Ryanodine Receptor Channels in Heart FailureR01HL074045 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GYORKE, SANDOR · 2003 to 2024
$8.2M
Toward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1M
The mechanisms and roles of mitochondria dysfunction in cardiac arrhythmogenesisR01HL166604 · NHLBI · OHIO STATE UNIVERSITY · PI Dmitry A Terentyev · 2023 to 2026
$2.8M
Novel Mechanisms of Regulation of SK channels: Implications for Cardiac ArrhythmiaR01HL142588 · NHLBI · OHIO STATE UNIVERSITY · PI TERENTYEV, DMITRY A · 2019 to 2022
$2.4M
Surgical Cardioprotection Through BKCa-Dependent Modulation of Mitochondrial SupercomplexesR01HL135236 · NHLBI · UNIVERSITY OF RHODE ISLAND · PI CLEMENTS, RICHARD T · 2018 to 2021
$1.9M
Role of SR-mitochondria interplay in calcium-dependent arrhythmiasR01HL166169 · NHLBI · UNIVERSITY OF FLORIDA · PI Bin Liu · 2024 to 2026
$1.4M
Cardiac ryanodine receptor and oxidative stressR00HL155492 · NHLBI · UNIVERSITY OF ARIZONA · PI HAMILTON, SHANNA · 2023 to 2025
$747k
Defining the role of KCNN1 in atrial arrhythmiasR03TR004471 · NCATS · OHIO STATE UNIVERSITY · PI TERENTYEV, DMITRY A · 2023 to 2023
methodsA mouse CASQ2 KO (calsequestrin type 2 knockout) model of catecholaminergic polymorphic ventricular tachycardia (CPVT) was used for in vivo ECG recordings and for cell electrophysiology, Ca
resultsBidirectional and polymorphic ventricular tachycardias in CASQ2 KO mice induced by stress challenge (epinephrine+caffeine cocktail) were attenuated by injection of NS309, a specific SK channel enhancer. Voltage-clamp experiments in isolated VMs treated with β-adrenergic agonist isoproterenol showed a reduction of sarcolemmal SK channel current (I
conclusionsSarcolemmal SK channel enhancement reduces arrhythmic potential by restoring repolarization force in CPVT VMs. Activation of mitochondrial SK channels attenuates mitochondria structural changes in CPVT, restoring more efficient electron transport chain assembly into supercomplexes and reducing mito-reactive oxygen species production. This decreases RyR2 oxidation and thus channel activity, reducing spontaneous Ca
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Pharmacological Enhancement of Small Conductance Ca · full record | OpenQuestion