Evidence map›Paper›PMID 40438856›Full record

ArticleCureus2025

Infective Endocarditis and Septic Emboli: Diagnostic Delays, Implications, and Challenges.

Ali M Ibnian, Maria Elizabeth Vincent, Jovita Amadi

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ali M IbnianInternal Medicine, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, GBR.
Maria Elizabeth VincentInternal Medicine, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, GBR.
Jovita AmadiInternal Medicine, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infective endocarditis (IE) presents significant diagnostic challenges and needs a high index of clinical suspicion. This study describes a case illustrating these complexities. A 69-year-old woman initially presented with confusion and expressive dysphasia, following five days of treatment for left-sided otitis media. Further investigations revealed evidence of Streptococcus infection. The patient was diagnosed with pneumococcal infective endocarditis, complicated by intracranial septic emboli and multiorgan failure. This resulted in prolonged hospital stay and the development of multi-morbidity and increased frailty index. IE was diagnosed only upon readmission, leading to delays in treatment. This study underscores the importance of early suspicion and repeat investigations in IE. Evolving diagnostic criteria emphasize a multidisciplinary approach to managing these life-threatening conditions.

Indexed as

austrian syndromecardiac vegetationscerebral septic emboliinfective endocarditisosler's triadstreptococcus pneumoniae infective endocarditis

Identifiers

PMID40438856
PMCPMC12117592

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.