ArticleCureus2025
Early Results of PreserFlo MicroShunt Implantation in Complicated Cases: A Single-Center Case Series.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe report the initial outcomes, early complications, and management of PreserFlo MicroShunt (Santen Pharmaceutical Co., Ltd., Osaka, Japan) implantation in complicated glaucoma cases.
methodsThis was a retrospective study.
resultsA case series of 12 patients with various glaucoma etiologies underwent PreserFlo MicroShunt surgery at Hospital Canselor Tuanku Muhriz, Kuala Lumpur, Malaysia, from September 2022 to June 2023. Best-corrected visual acuity (BCVA), intraocular pressure (IOP), IOP-lowering medications, and postoperative complications were assessed. All procedures were augmented with intraoperative mitomycin C (0.2 mg/mL). Among the 12 patients (eight males, four females), five (42%) had primary open-angle glaucoma (OAG), five (42%) had secondary OAG, and one (8%) each had ocular hypertension and primary angle closure. Postoperatively, all patients except one showed significant IOP and medication reduction. Mean IOP decreased from 23.75 ± 8.82 to 15.67 ± 10.18 mmHg (34% reduction, p < 0.001), and mean IOP-lowering medications reduced from 4.58 to 0.08 (98% reduction, p < 0.001). Complications included wipeout syndrome due to hypotony (8%) and overfiltration hypotony (16%), with one requiring surgical revision and later a glaucoma drainage device.
conclusionOur early results suggest PreserFlo MicroShunt is effective in lowering IOP and medications, but is associated with complications.
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