Evidence map›Paper›PMID 40438700›Full record

ArticleProceedings. IEEE International Symposium on Biomedical Imaging2024

ENLARGED PERIVASCULAR SPACES IN FRONTAL AND TEMPORAL CORTICAL REGIONS CHARACTERIZE SEIZURE OUTCOME AFTER TRAUMATIC BRAIN INJURY.

Celina Alba, Giuseppe Barisano, Alexis Bennett, Akul Sharma, Paul V Espa, Dominique Duncan

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PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings. IEEE International Symposium on Biomedical Imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Celina AlbaUSC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Giuseppe BarisanoDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Alexis BennettUSC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Akul SharmaUSC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Paul V EspaDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Dominique DuncanUSC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2017 to 2021
$21.7M
SCH: INT: Collaborative Research: Multimodal Signal Analysis and Data Fusion for Post-traumatic EpilepsyR01NS111744 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUNCAN, DOMINIQUE, ERDOGMUS, DENIZ · 2019 to 2022
$981k
NINDS NIH HHS R01 NS111744NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

Post-traumatic epilepsy (PTE) is characterized by seizures that occur at least one week after traumatic brain injury (TBI). Although PTE remains one of the most life-altering outcomes of TBI, there are no preventative treatments. The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is an international project designed to identify multimodal biomarkers of PTE; early EpiBioS4Rx research suggests that features of perivascular spaces (PVS) are a potential biomarker. This study evaluates the association between volume fraction (VF), the volume of PVS relative to total brain volume, and seizure activity. Structural magnetic resonance (MR) imaging from a subset of 62 EpiBioS4Rx subjects was used to create Enhanced PVS Contrast (EPC) imaging to segment and quantify PVS metrics. A multiple logistic regression model that controlled for demographic and clinical factors revealed a significant difference between the late seizure-positive and seizure-negative groups in the paracentral lobule, precentral gyrus, and temporal pole of the right hemisphere. These findings are supported by prior literature that identify a relationship between PVS function in these regions and seizure activity after TBI.

Indexed as

neuroimagingperivascular spacespost-traumatic epilepsytraumatic brain injury

Identifiers

PMID40438700
PMCPMC12119173

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.