ArticleFrontiers in neuroscience2025
Investigating the spatial limits of somatotopic and depth-dependent sensory discrimination stimuli in rats via intracortical microstimulation.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Linking spatially distributed neuronal activation overlap to the limits of perceptual discrimination in rodent primary somatosensory cortex.Frontiers in computational neuroscience · 2026Article
- Piezo1 and Piezo2 Ion Channels in Neuronal and Astrocytic Responses to MEA Implants in the Rat Somatosensory Cortex.International journal of molecular sciences · 2025Article
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16 authors.
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Abstract
The somatosensory cortex can be electrically stimulated via intracortical microelectrode arrays (MEAs) to induce a range of vibrotactile sensations. While previous studies have employed multi-shank MEA configurations to map somatotopic relationships, the influence of cortical depth on sensory discrimination remains relatively unexplored. In this study, we introduce a novel approach for investigating the spatial limits of stimulation-evoked sensory discrimination based on cortical depth and somatotopic relationships in rodents. To achieve this, we implanted single-shank and four-shank 16-channel MEAs into the primary somatosensory cortex of male rats. Then, we defined distinct stimulation patterns for comparison, each consisting of four simultaneously stimulated electrode sites separated along the length of the single-shank device or between shanks for the four-shank device. Next, we utilized a nose-poking, two-choice sensory discrimination task to evaluate each rat's ability to accurately differentiate between these patterns. We demonstrate that the rats were able to reliably discriminate between the most superficial (450-750 μm) and deepest (1650-1950 μm) single-shank patterns with 90% accuracy, whereas discrimination between the most superficial and next adjacent pattern (650-950 μm) significantly dropped to 53% (
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