ArticleJournal of pain research2025
NMRAL1 as a Causal Factor in Postherpetic Neuralgia: A Proteome-Wide Mendelian Randomization Study.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Immunological, Inflammatory, and Microbiota Determinants of Carpal Tunnel Syndrome: Evidence from Mendelian Randomization.Endocrine, metabolic & immune disorders drug targets · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postherpetic neuralgia (PHN) is a chronic pain condition following herpes zoster infection, disproportionately affecting elderly and immunocompromised individuals. Despite its significant clinical impact, the underlying mechanisms of PHN remain exclusive, and effective treatments are limited. Circulating plasma proteins offer insights into PHN pathogenesis and serve as potential biomarkers or therapeutic targets. Methods: We analyzed FinnGen R12 GWAS data (490 PHN cases and 435,371 controls) and protein quantitative trait loci (pQTL) data for 4907 plasma proteins from 35,559 Icelanders. Mendelian randomization (MR) was conducted to investigate causal associations between plasma proteins and PHN risk. Causal effects were assessed using inverse variance weighting (IVW) and MR-Egger methods. Results: MR analysis identified NMRAL1 as the only plasma protein causally associated with PHN. Genetically predicted higher levels of NMRAL1 were linked to a reduced risk of PHN (IVW odds ratio = 0.553, 95% confidence interval: 0.405-0.755, p = 0.000193). No evidence of heterogeneity or pleiotropy was observed, and sensitivity analyses, including leave-one-out analysis, confirmed the robustness of the findings. No other plasma proteins showed significant associations with PHN. Conclusion: This study identifies NMRAL1 as a protective factor for PHN and underscores its potential as a biomarker and therapeutic target. The findings highlight the utility of integrating proteomic and genetic data to advance understanding of complex neurological disorders like PHN.
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