ArticleAdvances in laboratory medicine2025
How to handle lipemic CBC samples on Sysmex hematology analyzers?
Article in Advances in laboratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Lipid Interference Flagging and Haemoglobin Correction in Lipemic Samples With a Hematology Analyzer.Journal of clinical laboratory analysis · 2026Article
- Article
- Clinical utility of optical scatter-derived red blood cell parameters for the rapid identification and correction of lipemic interference.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Lipemia poses a significant preanalytical problem for complete blood count (CBC) measurement due to limited and non-standardized methods for recognition and removal. We aimed to verify the optical hemoglobin (Hb-O) measurements on the Sysmex XN-1000 hematology analyzer (HA) as a possible reliable method for managing lipemic CBC samples. Methods: Ninety CBC samples with varying Hb concentrations were gradually spiked with a lipid emulsion. Measurements were repeated and Hb-O concentrations were recorded. Spiked CBC samples were centrifuged (400 Results: Hb-O showed statistically insignificant and acceptable bias compared to the initial Hb measurement according to the strictest acceptability criteria (-0.4 %, 95 % CI: -1.2-0.3, p=0.2447). The observed bias did not correlate with the degree of lipemia (rho=-0.072, 95 % CI: -0.295 to 0.157, p=0.537). Hemoglobin measured in samples with lipemic plasma replaced by analyzer diluent exhibited minimal, albeit statistically significant, bias (-1.1 %, 95 % CI: -2.0 to (-0.1), p=0.025). The observed bias negatively correlated with the degree of lipemia (rho=-0.369, 95 % CI: -0.550 to (-0.155), p=0.001). The highest unacceptable bias was found in the recalculated hemoglobin values based on the measured plasma hemoglobin (-3.5 %, 95 % CI: -4.1 to (-2.9), p<0.0001). Conclusions: Hb-O measurement is the most reliable measure of lipemia removal in CBC samples on the Sysmex XN-1000 HA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.