ArticleACG case reports journal2025
Drug Reaction With Eosinophilia and Systemic Symptoms and Severe Drug-Induced Liver Injury After Off-Label Zonisamide Use for Weight Loss.
Article in ACG case reports journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- [Research advances on the role of eosinophils in acute liver injury].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
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7 authors.
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Abstract
Drug-related eosinophilia with systemic symptoms (DRESS) is a drug-induced hypersensitivity reaction causing rash and systemic symptoms. Associated liver injury ranges from abnormal laboratory results to liver failure. We report a case of zonisamide-induced DRESS with severe liver injury, characterized by vanishing bile duct syndrome. Despite stopping zonisamide and initiating immunosuppressive therapy, the patient's hepatic function remained abnormal. After a prolonged course, the patient died from pneumonia and Hodgkin lymphoma. This case highlights the gravity of DRESS syndrome and drug-induced liver injury along with the risks of immunosuppressive therapies.
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