Evidence map›Paper›PMID 40438433›Full record

Observational studyEthiopian journal of health sciences2024

Assessment of Drug-related Problems among Patients of Chronic liver Disease in a Tertiary Care Hospital.

M J S Twinkle, Rahifa Ziyad Karjal, A Anushree, Adhiti Kellarai, Bipin Shaji, Shraddha Shetty, P Ramkumar, Juno Jerold Joel

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Ethiopian journal of health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M J S TwinkleNitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmacy Practice, Deralakatte, Mangaluru, India.
Rahifa Ziyad KarjalNitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmacy Practice, Deralakatte, Mangaluru, India.
A AnushreeNitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmacy Practice, Deralakatte, Mangaluru, India.
Adhiti KellaraiNitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Department of General Medicine, Deralakatte, Mangaluru, India.
Bipin ShajiNitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmacy Practice, Deralakatte, Mangaluru, India.
Shraddha ShettyNitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Department of Biostatistics, Deralakatte, Mangaluru, India.
P RamkumarNitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmaceutics, Deralakatte, Mangaluru, India.
Juno Jerold JoelNitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmacy Practice, Deralakatte, Mangaluru, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic Liver Disease (CLD) is a long-term condition marked by a gradual decline in liver function. Patients with CLD often experience multimorbidity and polypharmacy, which can adversely affect their health outcomes. The objective of the current study is to identify and resolve the drug-related problems associated with chronic liver disease. Methods: This prospective observational study involved 150 patients with CLD over a six-month period. Eligible participants included individuals over 18 years old, diagnosed with CLD based on the Child-Pugh score, and currently receiving treatment. Drug-related problems (DRPs) were identified using the Pharmaceutical Care Network Europe (PCNE) classification version 9.1. Data analysis was conducted using Chi-square and Fisher's exact tests with SPSS software version 29. Results: A total of 212 DRPs were identified and resolved. The most frequent type of DRP was related to treatment efficacy, with 96 instances (45.29%). Within this category, the subcategory 'effect of drug treatment not optimal' was the most common, accounting for 45 patients (21.23%). Drug interactions were identified as the leading cause of DRPs, comprising 65 cases (30.66%). Most issues were addressed at the prescriber level, with 48.11% of interventions accepted by physicians. Conclusion: This study provides valuable insights into identifying and managing DRPs that can negatively impact treatment outcomes in CLD patients. The findings can assist healthcare professionals in prioritizing strategies to enhance clinical results.

Indexed as

Drug-Related Side Effects and Adverse ReactionsLiver DiseasesAdultAgedChronic DiseaseDrug InteractionsFemaleHumansMaleMiddle AgedPolypharmacyProspective StudiesTertiary Care CentersChild-Pugh scoreChronic Liver DiseaseMultimorbidityPolypharmacy

Identifiers

PMID40438433
PMCPMC12110266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.