Evidence map›Paper›PMID 40438396›Full record

ArticleFrontiers in endocrinology2025

Time in target range for systolic blood pressure and stroke in people with and without diabetes: the Kailuan prospective cohort study.

Yuxin Yang, Shouling Wu, Jingdi Zhang, Yang Liu, Mingjie Yin, Zhenyu Huo, Shuohua Chen, Guodong Wang, Yao Xiao, Yue Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuxin Yang *Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Shouling Wu *Department of Cardiology, Kailuan General Hospital, Tangshan, China.
Jingdi ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, North China University of Science and Technology, Tangshan, China.
Yang LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Mingjie YinDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, China.
Zhenyu HuoDepartment of Epidemiology and Biostatistics, School of Public Health, North China University of Science and Technology, Tangshan, China.
Shuohua ChenDepartment of Cardiology, Kailuan General Hospital, Tangshan, China.
Guodong WangDepartment of Cardiology, Kailuan General Hospital, Tangshan, China.
Yao XiaoDepartment of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Yue WangDepartment of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Yuanyuan LiDepartment of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Jiawen DengDepartment of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Tingting GengDepartment of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Hong ZhangDepartment of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Systolic blood pressure time in target range (SBP-TTR) is an independent risk factor for stroke. We aimed to investigate the associations of SBP-TTR with stroke among participants with or without diabetes using data from the Kailuan study. Methods: We included 28,591 participants [mean age, 57.5 years; 83.8% men; 23.2% with diabetes] from the Kailuan Study. Cox proportional hazards regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of SBP-TTR on stroke in individuals with and without diabetes. Results: After a median of 8.7 years follow-up, 2,206 stroke cases occurred. Among participants with diabetes, those with SBP-TTR 75%-100% (HR [95%CI]: 0.64 [0.49, 0.84]) had a lower risk of stroke compared to those with SBP-TTR 0%-25%. Among participants without diabetes, those with SBP-TTR 50%-75% (HR 0.75, 95% CI 0.64-0.88) and 75%-100% (HR [95%CI]: 0.62 [0.52, 0.73]) had a significantly lower risk of stroke. A significant interaction between diabetes status and SBP-TTR was observed ( Conclusion: Higher SBP-TTR was associated with a reduced risk of stroke among participants with or without diabetes. The findings underscore the importance of maintaining blood pressure within the target range to mitigate stroke risk, particularly emphasizing the need for stringent blood pressure control in diabetic patients.

Indexed as

Blood PressureDiabetes MellitusHypertensionStrokeAgedChinaFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRisk FactorsdiabetesKailuan studystrokesystolic blood pressuretime in target range

Identifiers

PMID40438396
PMCPMC12116358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.