Evidence map›Paper›PMID 40438386›Full record

ReviewEpilepsy & behavior reports2025

Responsive neurostimulation for patients with refractory mesial temporal lobe epilepsy: A systematic review and meta-analysis.

Eshita Sharma, Beatriz Westphalen Pomianoski, Rabbia Jabbar, Ayesha Ayesha, Yasmin Picanco Silva, Paweł Łajczak, Aisha Rizwan Ahmed, Oguz Kagan Sahin, Mir Wajid Majeed, Mohammed Raake and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Epilepsy & behavior reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Brain-computer interface: an update for the clinicians.Frontiers in human neuroscience · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eshita SharmaUCLA, Los Angeles, United States of America.
Beatriz Westphalen PomianoskiUniversity Nove de Julho, São Paulo, Brazil.
Rabbia JabbarFatima Memorial Hospital FMHCMD, Lahore, Pakistan.
Ayesha AyeshaShifa College of Medicine, Islamabad, Pakistan.
Yasmin Picanco SilvaHealthcare Institution of South Iceland, Selfoss, Iceland.
Paweł ŁajczakMedical University of Silesia, Katowice, Poland.
Aisha Rizwan AhmedJinnah Medical and Dental College, Karachi, Pakistan.
Oguz Kagan SahinAcibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Mir Wajid MajeedGovernment Medical College Srinagar, India.
Mohammed RaakeAnnamalai University, Chennai, India.
Walter FagundesUniversidade Federal do Espírito Santo, Vitória, Brazil.
Giovani NollFederal University of Rio Grande do Sul, Porto Alegre, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Responsive neurostimulation (RNS) is a well-established adjuvant therapy for reducing seizure frequency in adults with medically refractory partial-onset seizures, particularly in individuals who are either not candidates for surgical resection or remain seizure-prone post-surgery. However, its effectiveness in patients with mesial temporal lobe epilepsy (MTLE) remains unclear. This meta-analysis evaluates the efficacy of RNS therapy in individuals with medically refractory MTLE. A systematic search of PubMed, Cochrane, and Scopus databases was conducted to identify eligible studies. Outcomes assessed included mean seizure frequency reduction, responder rate (proportion of patients achieving ≥50 % reduction in seizure frequency), and the proportion of patients achieving seizure freedom within six months of follow-up. Statistical analyses were performed using STATA. Seven observational studies involving 207 patients were included. RNS was associated with a mean seizure frequency reduction of 68.76 % (95 % CI 57.16-80.37 %; I

Indexed as

Meta-analysisNeurostimulationRefractory epilepsySystematic reviewTemporal lobe epilepsy

Identifiers

PMID40438386
PMCPMC12118465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.